Sensory perception of sweet, bitter, and umami (glutamate) taste

Q: What compounds affect the Sensory perception of sweet, bitter, and umami (glutamate) taste pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the Sensory perception of sweet, bitter, and umami (glutamate) taste pathway (Reactome ID: R-HSA-9717207). These compounds target 28 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-971720728 genes43 compounds

The Sensory perception of sweet, bitter, and umami (glutamate) taste pathway (Reactome ID: R-HSA-9717207) involves 28 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GRM1 GRM4 SCN2A SCN3A SCN9A TAS1R3 TAS2R1 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R20 TAS2R3 TAS2R30 TAS2R31 TAS2R38 TAS2R39 TAS2R4 TAS2R40 TAS2R41 TAS2R43 TAS2R46 TAS2R5 TAS2R50 TAS2R7 TAS2R8 TRPM4 TRPM5

Compounds Affecting Sensory perception of sweet, bitter, and umami (glutamate) taste

#	Compound	Targets Hit	Studies
1	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
2	Saxitoxin	—	300
3	Lacosamide	—	297
4	Veratridine	—	300
5	Flunarizine Flunarizine is	—	299
6	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
7	Etidocaine	—	300
8	lidoflazine	—	278
9	Mianserin	—	299
10	Bupivacaine	—	300
11	Chlorpheniramine	—	298
12	Cinnarizine	—	299
13	Cyproheptadine	—	299
14	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
15	Dibucaine	—	299
16	dilazep	—	300
17	Hydroxyzine	—	298
18	Lidocaine	—	299
19	Nortriptyline	—	295
20	Phenobarbital	—	297
21	Phentolamine	—	300
22	Promethazine	—	296
23	protriptyline	—	296
24	Quinidine	—	298
25	Reserpine	—	297
26	Spermine	—	300
27	Glutamic Acid	—	297
28	Glutamic Acid	—	300
29	Strychnine	—	300
30	Lamotrigine	—	296
31	Phenytoin	—	300
32	Riluzole	—	298
33	Aconitine	—	300
34	Adenosine Triphosphate	—	300
35	Adenosine	—	298
36	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
37	Adenosine Monophosphate Adenine nucleotide containing	—	300
38	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
39	Clotrimazole	—	296
40	Phenylthiourea Phenylthiourea is	—	300
41	Ethylenethiourea	—	300
42	Ibotenic Acid	—	300
43	Sucrose	—	299

About the Sensory perception of sweet, bitter, and umami (glutamate) taste Pathway

The Sensory perception of sweet, bitter, and umami (glutamate) taste pathway is catalogued in Reactome (ID: R-HSA-9717207) and involves 28 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRM1, GRM4, SCN2A, SCN3A, SCN9A.