Signaling by ALK fusions and activated point mutants

Q: What compounds affect the Signaling by ALK fusions and activated point mutants pathway?

268 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by ALK fusions and activated point mutants pathway (Reactome ID: R-HSA-9725370). These compounds target 33 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-972537033 genes268 compounds

The Signaling by ALK fusions and activated point mutants pathway (Reactome ID: R-HSA-9725370) involves 33 genes and is affected by 268 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 ALK ATIC BCL2A1 CCNB1 CUL1 DNMT1 EIF2AK3 EML4 FOXM1 GRB2 HDAC1 JUN MAPK1 MAPK3 MAPK8 MAPK9 MCL1 MDM2 NPM1 PIK3CB PIK3R1 PIK3R2 PPM1B PTPN6 RBX1 STAT1 STAT3 STAT5A TP53+3 more

Compounds Affecting Signaling by ALK fusions and activated point mutants

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	sp600125	—	117
3	Methylene Blue	—	200
4	egcg	—	300
5	Sorafenib	—	300
6	Crizotinib	—	298
7	Hexachlorophene	—	300
8	Methotrexate	—	289
9	ninhydrin	—	300
10	Camptothecin	—	300
11	vinblastine sulfate	—	81
12	Azacitidine	—	298
13	Azacitidine	—	300
14	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
15	Niclosamide	—	299
16	Quercetin	—	300
17	Axitinib	—	298
18	plumbagin [Supplementary Concept]	—	300
19	cycloheximide	—	300
20	Vorinostat	—	299
21	Clotrimazole	—	296
22	Thioridazine	—	35
23	Nisoldipine	—	297
24	Nocodazole Nocodazole is	—	215
25	Oxyphenbutazone	—	300
26	pd98059	—	7
27	Sertraline	—	1,000
28	2-Chloroadenosine 2-Chloroadenosine.	—	300
29	Colchicine	—	300
30	withaferin	—	300
31	Anisomycin	—	247
32	cardamonin	—	180
33	alsterpaullone	—	12
34	kenpaullone	—	8
35	ly294002	—	11
36	Sirolimus	—	300
37	Bortezomib	—	300
38	Rotenone	—	300
39	Cladribine	—	297
40	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
41	Cytarabine	—	297
42	Melphalan	—	300
43	Dactinomycin	—	297
44	Daunorubicin	—	298
45	Disulfiram	—	297
46	Vitamin K 3	—	300
47	Trifluridine	—	295
48	Resveratrol	—	298
49	Ciclopirox	—	88
50	daph	—	2

About the Signaling by ALK fusions and activated point mutants Pathway

The Signaling by ALK fusions and activated point mutants pathway is catalogued in Reactome (ID: R-HSA-9725370) and involves 33 genes. In the BiohacksAI corpus, 268 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, ALK, ATIC, BCL2A1, CCNB1.