Developmental Cell Lineages of the Integumentary System

Q: What compounds affect the Developmental Cell Lineages of the Integumentary System pathway?

381 compounds in the BiohacksAI corpus have documented interactions with genes in the Developmental Cell Lineages of the Integumentary System pathway (Reactome ID: R-HSA-9734779). These compounds target 14 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-973477914 genes381 compounds

The Developmental Cell Lineages of the Integumentary System pathway (Reactome ID: R-HSA-9734779) involves 14 genes and is affected by 381 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCG2 ALDH1A1 EGFR ERBB2 ESR1 FABP5 KIT KLK5 KLK7 MME MUC1 PGR PRSS3 YAP1

Compounds Affecting Developmental Cell Lineages of the Integumentary System

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Genistein	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Daunorubicin	—	298
5	Resveratrol	—	298
6	Kaempferols	—	300
7	Dactinomycin	—	297
8	Estrone	—	300
9	Rotenone	—	300
10	cycloheximide	—	300
11	Bortezomib	—	300
12	Quercetin	—	300
13	chrysin	—	300
14	Axitinib	—	298
15	Emetine	—	298
16	Fenofibrate	—	297
17	Disulfiram	—	297
18	candesartan cilexetil [Supplementary Concept]	—	300
19	Levonorgestrel	—	292
20	Norgestrel	—	300
21	Ethinyl Estradiol	—	300
22	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
23	Methyltestosterone	—	300
24	Dehydroepiandrosterone	—	300
25	Dehydroepiandrosterone	—	300
26	Fulvestrant	—	295
27	Danazol	—	298
28	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
29	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
30	Dihydrotestosterone	—	300
31	Ethidium	—	300
32	Ethynodiol Diacetate	—	300
33	Flutamide	—	298
34	Colchicine	—	300
35	Estriol	—	300
36	Mestranol	—	300
37	Norethindrone	—	300
38	Oxymetholone	—	298
39	Testosterone Propionate	—	300
40	Gestrinone	—	221
41	Hexachlorophene	—	300
42	Lynestrenol	—	299
43	Phenoxybenzamine	—	21
44	Pueraria	—	300
45	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
46	Progesterone	—	299
47	Niclosamide	—	299
48	Triiodothyronine	—	300
49	vinblastine sulfate	—	81
50	Celecoxib	—	295

About the Developmental Cell Lineages of the Integumentary System Pathway

The Developmental Cell Lineages of the Integumentary System pathway is catalogued in Reactome (ID: R-HSA-9734779) and involves 14 genes. In the BiohacksAI corpus, 381 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCG2, ALDH1A1, EGFR, ERBB2, ESR1.