What compounds affect the Bacterial Infection Pathways pathway?

90 compounds in the BiohacksAI corpus have documented interactions with genes in the Bacterial Infection Pathways pathway (Reactome ID: R-HSA-9824439). These compounds target 23 genes within this pathway.

What genes are in the Bacterial Infection Pathways pathway?

The Bacterial Infection Pathways pathway involves 23 genes. Key genes include: CASP4, CTSG, EEF2, FURIN, GRB2, GSK3A, HBA1, HBA2, HBB, HSP90AA1.

Bacterial Infection Pathways

REACTOME PATHWAY

Reactome: R-HSA-982443923 genes90 compounds

The Bacterial Infection Pathways pathway (Reactome ID: R-HSA-9824439) involves 23 genes and is affected by 90 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP4 CTSG EEF2 FURIN GRB2 GSK3A HBA1 HBA2 HBB HSP90AA1 HSP90AB1 KPNB1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAPK1 MAPK3 MET NOS2 RAB7A SRC TLR2

Compounds Affecting Bacterial Infection Pathways

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Sorafenib	—	300
3	pd98059	—	7
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	trametinib	—	296
7	monorden	—	8
8	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	piceatannol	—	300
11	sp600125	—	117
12	Dasatinib	—	299
13	Crizotinib	—	298
14	Axitinib	—	298
15	Vemurafenib	—	298
16	diallyl trisulfide	—	246
17	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
18	triolimus [Supplementary Concept]	—	33
19	gedunin	—	54
20	celastrol	—	300
21	Novobiocin	—	300
22	caffeic acid	—	300
23	Masoprocol	—	300
24	Tetracycline	—	300
25	2-Chloroadenosine 2-Chloroadenosine.	—	300
26	ag490	—	14
27	Calcimycin	—	216
28	Clotrimazole	—	296
29	cycloheximide	—	300
30	Idarubicin	—	299
31	Nitroprusside	—	299
32	plumbagin [Supplementary Concept]	—	300
33	tyrphostin ag 1478	—	4
34	fisetin	—	78
35	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
36	withaferin	—	300
37	Chlorhexidine	—	299
38	Afatinib	—	297
39	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
40	Calcitriol	—	300
41	Ciclopirox	—	88
42	deguelin [Supplementary Concept]	—	151
43	Disulfiram	—	297
44	Hexachlorophene	—	300
45	Indazoles	—	300
46	Miconazole	—	298
47	specioside	—	6
48	Wortmannin	—	300
49	Progesterone	—	299
50	Benzalkonium Compounds	—	299

About the Bacterial Infection Pathways Pathway

The Bacterial Infection Pathways pathway is catalogued in Reactome (ID: R-HSA-9824439) and involves 23 genes. In the BiohacksAI corpus, 90 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP4, CTSG, EEF2, FURIN, GRB2.