What compounds affect the Growth hormone receptor signaling pathway?

61 compounds in the BiohacksAI corpus have documented interactions with genes in the Growth hormone receptor signaling pathway (Reactome ID: R-HSA-982772). These compounds target 10 genes within this pathway.

What genes are in the Growth hormone receptor signaling pathway?

The Growth hormone receptor signaling pathway involves 10 genes. Key genes include: ADAM17, JAK2, LYN, MAPK1, MAPK3, PTPN1, PTPN6, STAT1, STAT3, STAT5A.

Growth hormone receptor signaling

REACTOME PATHWAY

Reactome: R-HSA-98277210 genes61 compounds

The Growth hormone receptor signaling pathway (Reactome ID: R-HSA-982772) involves 10 genes and is affected by 61 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM17 JAK2 LYN MAPK1 MAPK3 PTPN1 PTPN6 STAT1 STAT3 STAT5A

Compounds Affecting Growth hormone receptor signaling

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	alsterpaullone	—	12
3	kenpaullone	—	8
4	Methylene Blue	—	200
5	plumbagin [Supplementary Concept]	—	300
6	pd98059	—	7
7	tyrphostin ag 1478	—	4
8	sp600125	—	117
9	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
10	Lithocholic Acid	—	300
11	trametinib	—	296
12	withaferin	—	300
13	celastrol	—	300
14	Dasatinib	—	299
15	streptonigrin	—	299
16	Clotrimazole	—	296
17	fisetin	—	78
18	Progesterone	—	299
19	2-Chloroadenosine 2-Chloroadenosine.	—	300
20	Benzalkonium Compounds	—	299
21	Calcimycin	—	216
22	daph	—	2
23	Diphenhydramine	—	14
24	ha1004	—	4
25	Loratadine	—	296
26	trequinsin hydrochloride	—	1
27	Oleanolic Acid	—	300
28	Ursolic Acid	—	300
29	Okadaic Acid	—	300
30	caffeic acid	—	300
31	Chlorogenic Acid	—	300
32	Oleic Acid	—	112
33	Mepentol [Supplementary Concept]	—	184
34	Evans Blue	—	300
35	Palmitic Acid	—	300
36	prunetin	—	35
37	Suramin	—	300
38	vanadates	—	284
39	Azauridine	—	300
40	Cladribine	—	297
41	2-Methoxyestradiol	—	300
42	Astemizole Antihistamine drug now withdrawn from	—	280
43	Azathioprine	—	300
44	Calcitriol	—	300
45	Camptothecin	—	300
46	Cytarabine	—	297
47	dihydrorotenone	—	13
48	Podophyllotoxin	—	14
49	Trifluridine	—	295
50	Tripterygium	—	300

About the Growth hormone receptor signaling Pathway

The Growth hormone receptor signaling pathway is catalogued in Reactome (ID: R-HSA-982772) and involves 10 genes. In the BiohacksAI corpus, 61 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, JAK2, LYN, MAPK1, MAPK3.