What compounds affect the RSV-host interactions pathway?

73 compounds in the BiohacksAI corpus have documented interactions with genes in the RSV-host interactions pathway (Reactome ID: R-HSA-9833110). These compounds target 12 genes within this pathway.

What genes are in the RSV-host interactions pathway?

The RSV-host interactions pathway involves 12 genes. Key genes include: CCNC, CDK19, CDK8, CREBBP, CX3CR1, EIF2AK2, EP300, IFNB1, RBX1, TLR2.

RSV-host interactions

REACTOME PATHWAY

Reactome: R-HSA-983311012 genes73 compounds

The RSV-host interactions pathway (Reactome ID: R-HSA-9833110) involves 12 genes and is affected by 73 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNC CDK19 CDK8 CREBBP CX3CR1 EIF2AK2 EP300 IFNB1 RBX1 TLR2 TLR3 TYK2

Compounds Affecting RSV-host interactions

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Crizotinib	—	298
3	sp600125	—	117
4	Axitinib	—	298
5	alsterpaullone	—	12
6	Camptothecin	—	300
7	Ouabain	—	300
8	withaferin	—	300
9	celastrol	—	300
10	Disulfiram	—	297
11	Idarubicin	—	299
12	Bortezomib	—	300
13	cycloheximide	—	300
14	Emetine	—	298
15	Proscillaridin	—	219
16	Dactinomycin	—	297
17	Daunorubicin	—	298
18	Epirubicin	—	300
19	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
20	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
21	Tripterygium	—	300
22	Azacitidine	—	298
23	Azacitidine	—	300
24	Calcimycin	—	216
25	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
26	kenpaullone	—	8
27	cbd	—	298
28	cannabidiol	—	296
29	Deslanoside Deacetyllanatoside C.	—	89
30	Digitoxin	—	300
31	Digoxin	—	299
32	Feprazone	—	63
33	Leflunomide	—	297
34	triolimus [Supplementary Concept]	—	33
35	Thapsigargin	—	300
36	Genistein	—	300
37	Sertraline	—	1,000
38	Nitrendipine	—	299
39	Phenylbutazone	—	300
40	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
41	Methylene Blue	—	200
42	Warfarin	—	1,000
43	Afatinib	—	297
44	C75-coenzyme	—	49
45	casin	—	10
46	Fluspirilene	—	74
47	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
48	Trabectedin	—	297
49	tyrphostin ag 1478	—	4
50	Budesonide	—	1,000

About the RSV-host interactions Pathway

The RSV-host interactions pathway is catalogued in Reactome (ID: R-HSA-9833110) and involves 12 genes. In the BiohacksAI corpus, 73 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNC, CDK19, CDK8, CREBBP, CX3CR1.