What compounds affect the PKR-mediated signaling pathway?

196 compounds in the BiohacksAI corpus have documented interactions with genes in the PKR-mediated signaling pathway (Reactome ID: R-HSA-9833482). These compounds target 35 genes within this pathway.

What genes are in the PKR-mediated signaling pathway?

The PKR-mediated signaling pathway involves 35 genes. Key genes include: CDK1, CHUK, EIF2AK2, HSPA1A, HSPA1B, HSPA8, IKBKB, NPM1, PPP2CA, PPP2R5A.

PKR-mediated signaling

REACTOME PATHWAY

Reactome: R-HSA-983348235 genes196 compounds

The PKR-mediated signaling pathway (Reactome ID: R-HSA-9833482) involves 35 genes and is affected by 196 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK1 CHUK EIF2AK2 HSPA1A HSPA1B HSPA8 IKBKB NPM1 PPP2CA PPP2R5A PTPN2 SNCA SPHK1 STAT1 STAT3 SUMO1 TARBP2 TP53 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3+5 more

Compounds Affecting PKR-mediated signaling

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Noscapine	—	300
4	Vincristine	—	299
5	Vorinostat	—	299
6	vinblastine sulfate	—	81
7	Demecolcine	—	246
8	Podophyllotoxin	—	14
9	Maytansine	—	300
10	Hexachlorophene	—	300
11	sp600125	—	117
12	Quercetin	—	300
13	celastrol	—	300
14	Adenosine Triphosphate	—	300
15	Crizotinib	—	298
16	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
17	Ergosterol	—	300
18	Methylene Blue	—	200
19	Bortezomib	—	300
20	Rotenone	—	300
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	Niclosamide	—	299
23	Axitinib	—	298
24	Genistein	—	300
25	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
26	Clotrimazole	—	296
27	chrysin	—	300
28	Clofibrate	—	299
29	Fenofibrate	—	297
30	Sertraline	—	1,000
31	Cinnarizine	—	299
32	Hydroxyurea	—	300
33	egcg	—	300
34	Lithocholic Acid	—	300
35	alsterpaullone	—	12
36	chicoric acid	—	117
37	Okadaic Acid	—	300
38	Ethidium	—	300
39	Ethinyl Estradiol	—	300
40	Azacitidine	—	298
41	Azacitidine	—	300
42	Azathioprine	—	300
43	Cladribine	—	297
44	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
45	Cytarabine	—	297
46	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
47	Melphalan	—	300
48	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
49	Methotrexate	—	289
50	Dactinomycin	—	297

About the PKR-mediated signaling Pathway

The PKR-mediated signaling pathway is catalogued in Reactome (ID: R-HSA-9833482) and involves 35 genes. In the BiohacksAI corpus, 196 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK1, CHUK, EIF2AK2, HSPA1A, HSPA1B.