What compounds affect the Signaling by the B Cell Receptor (BCR) pathway?

245 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by the B Cell Receptor (BCR) pathway (Reactome ID: R-HSA-983705). These compounds target 49 genes within this pathway.

What genes are in the Signaling by the B Cell Receptor (BCR) pathway?

The Signaling by the B Cell Receptor (BCR) pathway involves 49 genes. Key genes include: ADRM1, BLK, BTK, CHUK, CUL1, FKBP1A, FYN, GRB2, IKBKB, LYN.

Signaling by the B Cell Receptor (BCR)

REACTOME PATHWAY

Reactome: R-HSA-98370549 genes245 compounds

The Signaling by the B Cell Receptor (BCR) pathway (Reactome ID: R-HSA-983705) involves 49 genes and is affected by 245 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 BLK BTK CHUK CUL1 FKBP1A FYN GRB2 IKBKB LYN MAP3K7 NFKB1 NFKBIA PIK3CD PIK3R1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1+19 more

Compounds Affecting Signaling by the B Cell Receptor (BCR)

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Crizotinib	—	298
4	tyrphostin ag 1478	—	4
5	Sorafenib	—	300
6	Dasatinib	—	299
7	Quercetin	—	300
8	sp600125	—	117
9	ly294002	—	11
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	alsterpaullone	—	12
12	chicoric acid	—	117
13	Disulfiram	—	297
14	Podophyllotoxin	—	14
15	torin 1	—	10
16	Trifluridine	—	295
17	alpelisib	—	227
18	withaferin	—	300
19	pictilisib	—	25
20	Kaempferols	—	300
21	kenpaullone	—	8
22	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
23	egcg	—	300
24	Sirolimus	—	300
25	cycloheximide	—	300
26	Lovastatin	—	300
27	Axitinib	—	298
28	Ursolic Acid	—	300
29	Afatinib	—	297
30	celastrol	—	300
31	Cerulenin	—	300
32	Hexachlorophene	—	300
33	vinblastine sulfate	—	81
34	chrysin	—	300
35	daph	—	2
36	Ku 0063794 [Supplementary Concept]	—	7
37	Resveratrol	—	298
38	Rutin	—	300
39	Withania	—	500
40	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
41	tamarixetin	—	26
42	Genistein	—	300
43	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
44	Wortmannin	—	300
45	Ouabain	—	300
46	Atorvastatin	—	1,000
47	Simvastatin	—	1,000
48	Methotrexate	—	289
49	Chlorhexidine	—	299
50	Clofarabine	—	298

About the Signaling by the B Cell Receptor (BCR) Pathway

The Signaling by the B Cell Receptor (BCR) pathway is catalogued in Reactome (ID: R-HSA-983705) and involves 49 genes. In the BiohacksAI corpus, 245 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, BLK, BTK, CHUK, CUL1.