What compounds target HISTONE-LYSINE?

BiohacksAI has identified 175 compounds that interact with HISTONE-LYSINE (Histone-lysine N-methyltransferase NSD2 (human)). Top compounds include: Dasatinib, Axitinib, Azathioprine, Bortezomib, Crizotinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

HISTONE-LYSINE

Q: What is HISTONE-LYSINE (Histone-lysine N-methyltransferase NSD2)?

HISTONE-LYSINE is Histone-lysine N-methyltransferase NSD2 (human). It is a molecular target for 175 compounds documented in PubMed bioassay data. UniProt ID: O96028.

MOLECULAR TARGET

Histone-lysine N-methyltransferase NSD2 (human)

UniProt: O96028175 compounds

HISTONE-LYSINE (Histone-lysine N-methyltransferase NSD2 (human)) is targeted by 175 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HISTONE-LYSINE

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Dasatinib	2.08	7
2	Axitinib	1.95	6
3	Azathioprine	1.95	6
4	Bortezomib	1.95	6
5	Crizotinib	1.95	6
6	Disulfiram	1.95	6
7	Ouabain	1.95	6
8	Chlorhexidine	1.79	5
9	Methylene Blue	1.61	4
10	ag490	1.61	4
11	alpelisib	1.61	4
12	Methotrexate	1.61	4
13	Calcitriol	1.61	4
14	Clofarabine	1.61	4
15	Colchicine	1.61	4
16	cycloheximide	1.61	4
17	Decitabine	1.61	4
18	Deferasirox	1.61	4
19	deguelin [Supplementary Concept]	1.61	4
20	Digitoxin	1.61	4
21	Digoxin	1.61	4
22	Emetine	1.61	4
23	Gemcitabine	1.61	4
24	Leflunomide	1.61	4
25	Maprotiline	1.61	4
26	Melphalan	1.61	4
27	monorden	1.61	4
28	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	1.61	4
29	Nocodazole Nocodazole is	1.61	4
30	pictilisib	1.61	4
31	Podophyllotoxin	1.61	4
32	Proscillaridin	1.61	4
33	Sorafenib	1.61	4
34	sp600125	1.61	4
35	Thapsigargin	1.61	4
36	torin 1	1.61	4
37	trichostatic acid [Supplementary Concept] related to trichostatin	1.61	4
38	Trifluridine	1.61	4
39	Tripterygium	1.61	4
40	vinblastine sulfate	1.61	4
41	Vincristine	1.61	4
42	withaferin	1.61	4
43	Daunorubicin	1.39	3
44	Dexrazoxane	1.39	3
45	Ethinyl Estradiol	1.39	3
46	Lovastatin	1.39	3
47	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.10	2
48	Prednisolone	1.10	2
49	Quercetin	1.10	2
50	Sertraline	1.10	2

Showing top 50 of 175 compounds. Use the BiohacksAI search to explore all HISTONE-LYSINE modulators.

About HISTONE-LYSINE as a Drug Target

HISTONE-LYSINE (Histone-lysine N-methyltransferase NSD2 (human)) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 175 compounds with documented HISTONE-LYSINE interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HISTONE-LYSINE inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.