What compounds affect the Neuronal System pathway?

490 compounds in the BiohacksAI corpus have documented interactions with genes in the Neuronal System pathway (Reactome ID: R-HSA-112316). These compounds target 141 genes within this pathway.

What genes are in the Neuronal System pathway?

The Neuronal System pathway involves 141 genes. Key genes include: ABAT, ABCC8, ABCC9, ACHE, ADCY9, ALDH2, ALDH5A1, BCHE, CACNA1B, CACNA2D1.

Neuronal System

REACTOME PATHWAY

Reactome: R-HSA-112316141 genes490 compounds

The Neuronal System pathway (Reactome ID: R-HSA-112316) involves 141 genes and is affected by 490 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABAT ABCC8 ABCC9 ACHE ADCY9 ALDH2 ALDH5A1 BCHE CACNA1B CACNA2D1 CACNA2D2 CAMK1 CAMK2B CAMK2D CAMKK1 CAMKK2 CASK CHRNA1 CHRNA4 CHRND CHRNG CREB1 ERBB4 GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5+111 more

Compounds Affecting Neuronal System

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Ondansetron	—	299
3	gamma-Aminobutyric Acid	—	300
4	Nocodazole Nocodazole is	—	215
5	Picrotoxin	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Demecolcine	—	246
8	Podophyllotoxin	—	14
9	vinblastine sulfate	—	81
10	Vorinostat	—	299
11	Vincristine	—	299
12	Noscapine	—	300
13	chrysin	—	300
14	Maytansine	—	300
15	Glutamic Acid	—	297
16	Glutamic Acid	—	300
17	Bicuculline	—	300
18	Pregnanolone	—	298
19	Etomidate Imidazole derivative anesthetic and hypnotic with little effect on blood gases, ventilation, or	—	299
20	Aripiprazole	—	298
21	Carvedilol	—	296
22	sp600125	—	117
23	Androsterone	—	300
24	Ciprofloxacin	—	1,000
25	Etiocholanolone	—	300
26	Triiodothyronine	—	300
27	Quinidine	—	298
28	pentamidine	—	299
29	Sorafenib	—	300
30	Berberine	—	300
31	Niclosamide	—	299
32	Ursolic Acid	—	300
33	Adenosine Monophosphate Adenine nucleotide containing	—	300
34	Astemizole Antihistamine drug now withdrawn from	—	280
35	Thioridazine	—	35
36	Nisoldipine	—	297
37	Crizotinib	—	298
38	Rotenone	—	300
39	Clotrimazole	—	296
40	Amoxapine	—	259
41	Perphenazine	—	297
42	Disulfiram	—	297
43	Metoclopramide	—	297
44	Nortriptyline	—	295
45	Chlorhexidine	—	299
46	Ethidium	—	300
47	hydroxyfasudil [Supplementary Concept]	—	11
48	Eszopiclone	—	296
49	Proguanil	—	299
50	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76

About the Neuronal System Pathway

The Neuronal System pathway is catalogued in Reactome (ID: R-HSA-112316) and involves 141 genes. In the BiohacksAI corpus, 490 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABAT, ABCC8, ABCC9, ACHE, ADCY9.