What compounds affect the PIP3 activates AKT signaling pathway?

476 compounds in the BiohacksAI corpus have documented interactions with genes in the PIP3 activates AKT signaling pathway (Reactome ID: R-HSA-1257604). These compounds target 109 genes within this pathway.

What genes are in the PIP3 activates AKT signaling pathway?

The PIP3 activates AKT signaling pathway involves 109 genes. Key genes include: ADRM1, AGO2, AKT3, BAD, CASP9, CHUK, CREB1, CSNK2A1, CSNK2A2, CSNK2B.

PIP3 activates AKT signaling

REACTOME PATHWAY

Reactome: R-HSA-1257604109 genes476 compounds

The PIP3 activates AKT signaling pathway (Reactome ID: R-HSA-1257604) involves 109 genes and is affected by 476 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 AKT3 BAD CASP9 CHUK CREB1 CSNK2A1 CSNK2A2 CSNK2B EED EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 EZH2 FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FOXO3 FRK FYN GRB2 GSK3A GSK3B+79 more

Compounds Affecting PIP3 activates AKT signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	sp600125	—	117
3	Sorafenib	—	300
4	Quercetin	—	300
5	Dasatinib	—	299
6	Reserpine	—	297
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	pictilisib	—	25
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Crizotinib	—	298
11	Axitinib	—	298
12	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
13	ly294002	—	11
14	chrysin	—	300
15	Kaempferols	—	300
16	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
17	Daunorubicin	—	298
18	Sirolimus	—	300
19	kenpaullone	—	8
20	Afatinib	—	297
21	alsterpaullone	—	12
22	Resveratrol	—	298
23	Vorinostat	—	299
24	Disulfiram	—	297
25	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
26	Ursolic Acid	—	300
27	torin 1	—	10
28	tyrphostin ag 1478	—	4
29	Genistein	—	300
30	Camptothecin	—	300
31	Ku 0063794 [Supplementary Concept]	—	7
32	egcg	—	300
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	Dactinomycin	—	297
35	Rotenone	—	300
36	vinblastine sulfate	—	81
37	Celecoxib	—	295
38	Clotrimazole	—	296
39	Nisoldipine	—	297
40	Methylene Blue	—	200
41	Astemizole Antihistamine drug now withdrawn from	—	280
42	Wortmannin	—	300
43	fisetin	—	78
44	Ethidium	—	300
45	cycloheximide	—	300
46	Hexachlorophene	—	300
47	Niclosamide	—	299
48	Loratadine	—	296
49	Masoprocol	—	300
50	Chlorhexidine	—	299

About the PIP3 activates AKT signaling Pathway

The PIP3 activates AKT signaling pathway is catalogued in Reactome (ID: R-HSA-1257604) and involves 109 genes. In the BiohacksAI corpus, 476 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, AKT3, BAD, CASP9.