What compounds affect the Macroautophagy pathway?

187 compounds in the BiohacksAI corpus have documented interactions with genes in the Macroautophagy pathway (Reactome ID: R-HSA-1632852). These compounds target 47 genes within this pathway.

What genes are in the Macroautophagy pathway?

The Macroautophagy pathway involves 47 genes. Key genes include: ATG4B, ATM, CFTR, CSNK2A1, CSNK2A2, CSNK2B, EPAS1, HDAC6, HSP90AA1, HSPA8.

Macroautophagy

REACTOME PATHWAY

Reactome: R-HSA-163285247 genes187 compounds

The Macroautophagy pathway (Reactome ID: R-HSA-1632852) involves 47 genes and is affected by 187 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATG4B ATM CFTR CSNK2A1 CSNK2A2 CSNK2B EPAS1 HDAC6 HSP90AA1 HSPA8 MAP1LC3A MAP1LC3B MLST8 MTOR PIK3C3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKN RPTOR SRC TBK1 TUBA1A TUBA1B TUBA1C TUBA3C+17 more

Compounds Affecting Macroautophagy

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Vorinostat	—	299
4	Podophyllotoxin	—	14
5	vinblastine sulfate	—	81
6	Vincristine	—	299
7	Noscapine	—	300
8	Demecolcine	—	246
9	Maytansine	—	300
10	Niclosamide	—	299
11	Ursolic Acid	—	300
12	Quercetin	—	300
13	Rotenone	—	300
14	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
15	Adenosine Monophosphate Adenine nucleotide containing	—	300
16	Proguanil	—	299
17	Berberine	—	300
18	Antimycin	—	300
19	Oleanolic Acid	—	300
20	Metformin	—	1,000
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
23	Hexachlorophene	—	300
24	Kaempferols	—	300
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	kenpaullone	—	8
27	pictilisib	—	25
28	chrysin	—	300
29	fisetin	—	78
30	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
31	Wortmannin	—	300
32	torin 1	—	10
33	ly294002	—	11
34	Crizotinib	—	298
35	Genistein	—	300
36	cycloheximide	—	300
37	alsterpaullone	—	12
38	Disulfiram	—	297
39	Axitinib	—	298
40	piceatannol	—	300
41	Novobiocin	—	300
42	Calcimycin	—	216
43	Sirolimus	—	300
44	Everolimus	—	297
45	Ku 0063794 [Supplementary Concept]	—	7
46	Vanillic Acid	—	300
47	Anisomycin	—	247
48	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
49	Medroxyprogesterone Acetate	—	299
50	Mestranol	—	300

About the Macroautophagy Pathway

The Macroautophagy pathway is catalogued in Reactome (ID: R-HSA-1632852) and involves 47 genes. In the BiohacksAI corpus, 187 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATG4B, ATM, CFTR, CSNK2A1, CSNK2A2.