What compounds affect the Innate Immune System pathway?

510 compounds in the BiohacksAI corpus have documented interactions with genes in the Innate Immune System pathway (Reactome ID: R-HSA-168249). These compounds target 216 genes within this pathway.

What genes are in the Innate Immune System pathway?

The Innate Immune System pathway involves 216 genes. Key genes include: ABL1, ADAM10, ADRM1, AGL, ALOX5, AMPD3, ANXA2, AOC1, APP, ARSA.

Innate Immune System

REACTOME PATHWAY

Reactome: R-HSA-168249216 genes510 compounds

The Innate Immune System pathway (Reactome ID: R-HSA-168249) involves 216 genes and is affected by 510 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADAM10 ADRM1 AGL ALOX5 AMPD3 ANXA2 AOC1 APP ARSA ATP6V1B2 BCL2L1 BTK C5 C9 CAPN1 CASP1 CASP2 CASP4 CASP5 CASP9 CCR6 CCT2 CD47 CDA CDC42 CDK13 CFL1 CGAS CHUK+186 more

Compounds Affecting Innate Immune System

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Crizotinib	—	298
4	Quercetin	—	300
5	Dasatinib	—	299
6	sp600125	—	117
7	Disulfiram	—	297
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Reserpine	—	297
10	Afatinib	—	297
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	tyrphostin ag 1478	—	4
13	Axitinib	—	298
14	Hexachlorophene	—	300
15	withaferin	—	300
16	kenpaullone	—	8
17	cycloheximide	—	300
18	Anisomycin	—	247
19	pictilisib	—	25
20	Kaempferols	—	300
21	Resveratrol	—	298
22	egcg	—	300
23	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
24	Digoxin	—	299
25	Digitoxin	—	300
26	alsterpaullone	—	12
27	Genistein	—	300
28	Adenosine Triphosphate	—	300
29	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
30	Podophyllotoxin	—	14
31	fisetin	—	78
32	Methylene Blue	—	200
33	celastrol	—	300
34	Clotrimazole	—	296
35	vinblastine sulfate	—	81
36	Idarubicin	—	299
37	Oxyphenbutazone	—	300
38	Masoprocol	—	300
39	piceatannol	—	300
40	Nocodazole Nocodazole is	—	215
41	Sertraline	—	1,000
42	Ouabain	—	300
43	Chlorhexidine	—	299
44	Niclosamide	—	299
45	Camptothecin	—	300
46	Ethinyl Estradiol	—	300
47	Nisoldipine	—	297
48	triolimus [Supplementary Concept]	—	33
49	Vemurafenib	—	298
50	Azacitidine	—	298

About the Innate Immune System Pathway

The Innate Immune System pathway is catalogued in Reactome (ID: R-HSA-168249) and involves 216 genes. In the BiohacksAI corpus, 510 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADAM10, ADRM1, AGL, ALOX5.