What compounds affect the Influenza Infection pathway?

57 compounds in the BiohacksAI corpus have documented interactions with genes in the Influenza Infection pathway (Reactome ID: R-HSA-168255). These compounds target 9 genes within this pathway.

What genes are in the Influenza Infection pathway?

The Influenza Infection pathway involves 9 genes. Key genes include: EIF2AK2, HSP90AA1, HSPA1A, HSPA1B, KPNB1, PARP1, RAN, RPSA, XPO1.

Influenza Infection

REACTOME PATHWAY

Reactome: R-HSA-1682559 genes57 compounds

The Influenza Infection pathway (Reactome ID: R-HSA-168255) involves 9 genes and is affected by 57 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EIF2AK2 HSP90AA1 HSPA1A HSPA1B KPNB1 PARP1 RAN RPSA XPO1

Compounds Affecting Influenza Infection

#	Compound	Targets Hit	Studies
1	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
2	Ergosterol	—	300
3	Adenosine Triphosphate	—	300
4	Reserpine	—	297
5	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
6	triolimus [Supplementary Concept]	—	33
7	monorden	—	8
8	gedunin	—	54
9	celastrol	—	300
10	Novobiocin	—	300
11	caffeic acid	—	300
12	Masoprocol	—	300
13	Tetracycline	—	300
14	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Quercetin	—	300
17	2-Chloroadenosine 2-Chloroadenosine.	—	300
18	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
19	ag490	—	14
20	Calcimycin	—	216
21	Calcitriol	—	300
22	Ciclopirox	—	88
23	Clotrimazole	—	296
24	cycloheximide	—	300
25	deguelin [Supplementary Concept]	—	151
26	Disulfiram	—	297
27	Hexachlorophene	—	300
28	Idarubicin	—	299
29	Indazoles	—	300
30	Miconazole	—	298
31	piceatannol	—	300
32	Nitroprusside	—	299
33	specioside	—	6
34	Wortmannin	—	300
35	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
36	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
37	Bortezomib	—	300
38	Camptothecin	—	300
39	Clofarabine	—	298
40	Daunorubicin	—	298
41	Demecolcine	—	246
42	Epirubicin	—	300
43	Gemcitabine	—	300
44	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
45	Irinotecan	—	298
46	Nocodazole Nocodazole is	—	215
47	Podophyllotoxin	—	14
48	Teniposide	—	299
49	Thapsigargin	—	300
50	Trabectedin	—	297

About the Influenza Infection Pathway

The Influenza Infection pathway is catalogued in Reactome (ID: R-HSA-168255) and involves 9 genes. In the BiohacksAI corpus, 57 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EIF2AK2, HSP90AA1, HSPA1A, HSPA1B, KPNB1.