What compounds affect the Signaling by Hippo pathway?

48 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by Hippo pathway (Reactome ID: R-HSA-2028269). These compounds target 5 genes within this pathway.

What genes are in the Signaling by Hippo pathway?

The Signaling by Hippo pathway involves 5 genes. Key genes include: LATS1, STK3, STK4, YAP1, YWHAB.

Signaling by Hippo

REACTOME PATHWAY

Reactome: R-HSA-20282695 genes48 compounds

The Signaling by Hippo pathway (Reactome ID: R-HSA-2028269) involves 5 genes and is affected by 48 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

LATS1 STK3 STK4 YAP1 YWHAB

Compounds Affecting Signaling by Hippo

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Axitinib	—	298
3	Crizotinib	—	298
4	Colchicine	—	300
5	Resveratrol	—	298
6	Daunorubicin	—	298
7	Rotenone	—	300
8	Pueraria	—	300
9	Azacitidine	—	298
10	Azacitidine	—	300
11	Camptothecin	—	300
12	cycloheximide	—	300
13	Dactinomycin	—	297
14	deguelin [Supplementary Concept]	—	151
15	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
16	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
17	Ouabain	—	300
18	Podophyllotoxin	—	14
19	Thapsigargin	—	300
20	Berberine	—	300
21	Genistein	—	300
22	2-Methoxyestradiol	—	300
23	Anisomycin	—	247
24	Antimycin	—	300
25	Azauridine	—	300
26	Benzalkonium Compounds	—	299
27	celastrol	—	300
28	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
29	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
30	dihydrorotenone	—	13
31	Emetine	—	298
32	Gliotoxin	—	300
33	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
34	Monensin	—	300
35	Monocrotaline	—	300
36	Nigericin	—	300
37	Nocodazole Nocodazole is	—	215
38	Plicamycin	—	72
39	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
40	Tilorone	—	300
41	Tripterygium	—	300
42	Tubercidin	—	300
43	tyrphostin 9	—	2
44	Valinomycin	—	300
45	kenpaullone	—	8
46	alsterpaullone	—	12
47	Quercetin	—	300
48	hydroxyfasudil [Supplementary Concept]	—	11

About the Signaling by Hippo Pathway

The Signaling by Hippo pathway is catalogued in Reactome (ID: R-HSA-2028269) and involves 5 genes. In the BiohacksAI corpus, 48 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include LATS1, STK3, STK4, YAP1, YWHAB.