What compounds affect the SUMOylation pathway?

644 compounds in the BiohacksAI corpus have documented interactions with genes in the SUMOylation pathway (Reactome ID: R-HSA-2990846). These compounds target 58 genes within this pathway.

What genes are in the SUMOylation pathway?

The SUMOylation pathway involves 58 genes. Key genes include: AR, AURKA, AURKB, BIRC5, BLM, BRCA1, CREBBP, CTBP1, DNMT1, DNMT3B.

SUMOylation

REACTOME PATHWAY

Reactome: R-HSA-299084658 genes644 compounds

The SUMOylation pathway (Reactome ID: R-HSA-2990846) involves 58 genes and is affected by 644 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AR AURKA AURKB BIRC5 BLM BRCA1 CREBBP CTBP1 DNMT1 DNMT3B EIF2AK2 EP300 ESR1 HDAC1 HDAC2 HDAC4 HDAC7 HIPK2 IKBKE MDM2 MITF NCOA1 NCOR2 NFKB2 NFKBIA NPM1 NR1H2 NR1H3 NR1H4 NR1I2+28 more

Compounds Affecting SUMOylation

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Ethidium	—	300
3	vinblastine sulfate	—	81
4	Progesterone	—	299
5	cycloheximide	—	300
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Methylene Blue	—	200
10	Quercetin	—	300
11	Hexachlorophene	—	300
12	Podophyllotoxin	—	14
13	Resveratrol	—	298
14	Bortezomib	—	300
15	Triiodothyronine	—	300
16	Spironolactone	—	298
17	Genistein	—	300
18	Nocodazole Nocodazole is	—	215
19	Dactinomycin	—	297
20	Digoxin	—	299
21	Kaempferols	—	300
22	Dinitrochlorobenzene	—	300
23	Celecoxib	—	295
24	Colchicine	—	300
25	chrysin	—	300
26	Niclosamide	—	299
27	Troglitazone	—	299
28	Aldosterone	—	300
29	Vorinostat	—	299
30	Methotrexate	—	289
31	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
32	Dihydrotestosterone	—	300
33	Chlorhexidine	—	299
34	Nisoldipine	—	297
35	Clotrimazole	—	296
36	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
37	Astemizole Antihistamine drug now withdrawn from	—	280
38	Dasatinib	—	299
39	Emetine	—	298
40	Vincristine	—	299
41	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
42	rafoxanide	—	172
43	Camptothecin	—	300
44	Ethinyl Estradiol	—	300
45	Disulfiram	—	297
46	Rotenone	—	300
47	Loratadine	—	296
48	Ciclopirox	—	88
49	Melphalan	—	300
50	o-Phthalaldehyde	—	300

About the SUMOylation Pathway

The SUMOylation pathway is catalogued in Reactome (ID: R-HSA-2990846) and involves 58 genes. In the BiohacksAI corpus, 644 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AR, AURKA, AURKB, BIRC5, BLM.