What compounds affect the PKMTs methylate histone lysines pathway?

216 compounds in the BiohacksAI corpus have documented interactions with genes in the PKMTs methylate histone lysines pathway (Reactome ID: R-HSA-3214841). These compounds target 20 genes within this pathway.

What genes are in the PKMTs methylate histone lysines pathway?

The PKMTs methylate histone lysines pathway involves 20 genes. Key genes include: ASH2L, DOT1L, DPY30, EED, EHMT1, EHMT2, EZH2, KMT2A, KMT5A, KMT5C.

PKMTs methylate histone lysines

REACTOME PATHWAY

Reactome: R-HSA-321484120 genes216 compounds

The PKMTs methylate histone lysines pathway (Reactome ID: R-HSA-3214841) involves 20 genes and is affected by 216 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ASH2L DOT1L DPY30 EED EHMT1 EHMT2 EZH2 KMT2A KMT5A KMT5C NFKB1 NFKB2 NSD2 RBBP5 RELA SETD7 SETDB1 SMYD2 SUV39H1 WDR5

Compounds Affecting PKMTs methylate histone lysines

#	Compound	Targets Hit	Studies
1	s adenosylhomocysteine	—	300
2	Cyproheptadine	—	299
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Quercetin	—	300
5	Bortezomib	—	300
6	Disulfiram	—	297
7	withaferin	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Kaempferols	—	300
10	Podophyllotoxin	—	14
11	Trifluridine	—	295
12	scutellarein	—	113
13	Resveratrol	—	298
14	Rutin	—	300
15	Withania	—	500
16	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
17	tamarixetin	—	26
18	Sorafenib	—	300
19	vinblastine sulfate	—	81
20	Lovastatin	—	300
21	Hydrocortisone	—	299
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Cerulenin	—	300
24	Hexachlorophene	—	300
25	Hydrocortisone	—	298
26	ly294002	—	11
27	tyrphostin ag 1478	—	4
28	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
29	Biotin	—	297
30	Triamcinolone	—	300
31	Gliotoxin	—	300
32	Glutathione	—	300
33	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
34	Dimethyl Sulfoxide	—	300
35	ninhydrin	—	300
36	Dasatinib	—	299
37	Axitinib	—	298
38	Azathioprine	—	300
39	Crizotinib	—	298
40	Ouabain	—	300
41	Methylene Blue	—	200
42	Maprotiline	—	299
43	Atorvastatin	—	1,000
44	ag490	—	14
45	alpelisib	—	227
46	Methotrexate	—	289
47	Calcitriol	—	300
48	Chlorhexidine	—	299
49	Clofarabine	—	298
50	Colchicine	—	300

About the PKMTs methylate histone lysines Pathway

The PKMTs methylate histone lysines pathway is catalogued in Reactome (ID: R-HSA-3214841) and involves 20 genes. In the BiohacksAI corpus, 216 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ASH2L, DOT1L, DPY30, EED, EHMT1.