Loss of proteins required for interphase microtubule organization from the centrosome

Q: What compounds affect the Loss of proteins required for interphase microtubule organization from the centrosome pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the Loss of proteins required for interphase microtubule organization from the centrosome pathway (Reactome ID: R-HSA-380284). These compounds target 14 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-38028414 genes71 compounds

The Loss of proteins required for interphase microtubule organization from the centrosome pathway (Reactome ID: R-HSA-380284) involves 14 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK1 CSNK1D CSNK1E HSP90AA1 NEK2 PLK1 PLK4 PRKACA TUBA1A TUBA4A TUBB TUBB4A TUBB4B YWHAG

Compounds Affecting Loss of proteins required for interphase microtubule organization from the centrosome

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Podophyllotoxin	—	14
5	Vincristine	—	299
6	Demecolcine	—	246
7	Maytansine	—	300
8	Noscapine	—	300
9	vinblastine sulfate	—	81
10	Vorinostat	—	299
11	Quercetin	—	300
12	alsterpaullone	—	12
13	pictilisib	—	25
14	Masoprocol	—	300
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Clotrimazole	—	296
17	Disulfiram	—	297
18	Hexachlorophene	—	300
19	Idarubicin	—	299
20	Wortmannin	—	300
21	kenpaullone	—	8
22	Sorafenib	—	300
23	Dasatinib	—	299
24	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
25	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
26	triolimus [Supplementary Concept]	—	33
27	monorden	—	8
28	gedunin	—	54
29	celastrol	—	300
30	Novobiocin	—	300
31	caffeic acid	—	300
32	Tetracycline	—	300
33	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
34	2-Chloroadenosine 2-Chloroadenosine.	—	300
35	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
36	ag490	—	14
37	Calcimycin	—	216
38	Calcitriol	—	300
39	Ciclopirox	—	88
40	cycloheximide	—	300
41	deguelin [Supplementary Concept]	—	151
42	Indazoles	—	300
43	Miconazole	—	298
44	piceatannol	—	300
45	Nitroprusside	—	299
46	specioside	—	6
47	indirubin	—	300
48	Clofibrate	—	299
49	Fenofibrate	—	297
50	Sertraline	—	1,000

About the Loss of proteins required for interphase microtubule organization from the centrosome Pathway

The Loss of proteins required for interphase microtubule organization from the centrosome pathway is catalogued in Reactome (ID: R-HSA-380284) and involves 14 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK1, CSNK1D, CSNK1E, HSP90AA1, NEK2.