What compounds affect the Transport of small molecules pathway?

541 compounds in the BiohacksAI corpus have documented interactions with genes in the Transport of small molecules pathway (Reactome ID: R-HSA-382551). These compounds target 166 genes within this pathway.

What genes are in the Transport of small molecules pathway?

The Transport of small molecules pathway involves 166 genes. Key genes include: ABCB1, ABCB6, ABCC1, ABCC2, ABCC3, ABCC4, ABCC5, ABCC9, ABCG2, ADCY9.

Transport of small molecules

REACTOME PATHWAY

Reactome: R-HSA-382551166 genes541 compounds

The Transport of small molecules pathway (Reactome ID: R-HSA-382551) involves 166 genes and is affected by 541 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB1 ABCB6 ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 ABCC9 ABCG2 ADCY9 ADRM1 ALB ASIC3 ASPH ATP12A ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP4A ATP4B ATP6V1B2 AVPR2 CA1+136 more

Compounds Affecting Transport of small molecules

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Digoxin	—	299
4	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
5	Quercetin	—	300
6	Digitoxin	—	300
7	Bumetanide	—	299
8	Ouabain	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Chlorhexidine	—	299
11	Genistein	—	300
12	Clotrimazole	—	296
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	Dinoprostone	—	296
15	Hexachlorophene	—	300
16	Glyburide	—	298
17	Furosemide	—	298
18	Resveratrol	—	298
19	Carvedilol	—	296
20	Ritonavir	—	298
21	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
22	chrysin	—	300
23	Kaempferols	—	300
24	Indomethacin	—	297
25	pentamidine	—	299
26	Famotidine	—	296
27	Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as	—	300
28	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
29	Ceftriaxone	—	299
30	Dinoprost	—	252
31	Adenosine	—	298
32	Quinidine	—	298
33	Progesterone	—	299
34	Delavirdine	—	296
35	Thyroxine	—	994
36	Sirolimus	—	300
37	Sertraline	—	1,000
38	Amoxapine	—	259
39	Disulfiram	—	297
40	lidoflazine	—	278
41	Thyroxine	—	300
42	hydroxyfasudil [Supplementary Concept]	—	11
43	Histidine	—	158
44	Olmesartan Medoxomil	—	300
45	candesartan cilexetil [Supplementary Concept]	—	300
46	Triiodothyronine	—	300
47	Cimetidine	—	299
48	Adenosine Triphosphate	—	300
49	Astemizole Antihistamine drug now withdrawn from	—	280
50	Simvastatin	—	1,000

About the Transport of small molecules Pathway

The Transport of small molecules pathway is catalogued in Reactome (ID: R-HSA-382551) and involves 166 genes. In the BiohacksAI corpus, 541 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB1, ABCB6, ABCC1, ABCC2, ABCC3.