What compounds affect the Dopamine receptors pathway?

202 compounds in the BiohacksAI corpus have documented interactions with genes in the Dopamine receptors pathway (Reactome ID: R-HSA-390651). These compounds target 5 genes within this pathway.

What genes are in the Dopamine receptors pathway?

The Dopamine receptors pathway involves 5 genes. Key genes include: DRD1, DRD2, DRD3, DRD4, DRD5.

Dopamine receptors

REACTOME PATHWAY

Reactome: R-HSA-3906515 genes202 compounds

The Dopamine receptors pathway (Reactome ID: R-HSA-390651) involves 5 genes and is affected by 202 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

DRD1 DRD2 DRD3 DRD4 DRD5

Compounds Affecting Dopamine receptors

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Sulpiride	—	299
3	Pergolide	—	299
4	Butaclamol	—	300
5	Bromocriptine	—	299
6	Raclopride	—	300
7	Cabergoline	—	299
8	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
9	Lisuride	—	299
10	Loxapine	—	225
11	Yohimbine	—	299
12	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
13	Buspirone	—	299
14	Amoxapine	—	259
15	Cyproheptadine	—	299
16	Tetrahydropapaveroline	—	139
17	Quetiapine Fumarate	—	994
18	Mianserin	—	299
19	Metergoline	—	144
20	nafadotride	—	14
21	Astemizole Antihistamine drug now withdrawn from	—	280
22	Dihydroergotamine	—	9
23	Promethazine	—	296
24	Carvedilol	—	296
25	Meclizine	—	121
26	Trazodone	—	297
27	Pramipexole	—	297
28	Domperidone	—	299
29	Metoclopramide	—	297
30	Piribedil	—	300
31	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
32	Maprotiline	—	299
33	Methylergonovine	—	193
34	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
35	Cinnarizine	—	299
36	lidoflazine	—	278
37	oxatomide [Supplementary Concept] structure;	—	128
38	Duloxetine Hydrochloride	—	993
39	Chlorhexidine	—	299
40	chlorprothixene hydrochloride	—	1
41	Dihydroergocornine	—	65
42	Dihydroergotamine	—	299
43	Epinephrine	—	299
44	Ergotamine	—	299
45	Flunarizine Flunarizine is	—	299
46	Hydroxyzine	—	298
47	Loxapine	—	30
48	Methysergide	—	300
49	Nicergoline	—	300
50	Nortriptyline	—	295

About the Dopamine receptors Pathway

The Dopamine receptors pathway is catalogued in Reactome (ID: R-HSA-390651) and involves 5 genes. In the BiohacksAI corpus, 202 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include DRD1, DRD2, DRD3, DRD4, DRD5.