Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)

Q: What compounds affect the Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) pathway?

70 compounds in the BiohacksAI corpus have documented interactions with genes in the Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) pathway (Reactome ID: R-HSA-5619081). These compounds target 1 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-56190811 genes70 compounds

The Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) pathway (Reactome ID: R-HSA-5619081) involves 1 genes and is affected by 70 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

SLC6A3

Compounds Affecting Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)

#	Compound	Targets Hit	Studies
1	Duloxetine Hydrochloride	—	993
2	Fluoxetine	—	1,000
3	Modafinil	—	297
4	Sertraline	—	1,000
5	Venlafaxine Hydrochloride	—	1,000
6	Digoxin	—	299
7	Ouabain	—	300
8	Ticagrelor	—	299
9	Amlodipine	—	1,000
10	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
11	Aripiprazole	—	298
12	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
13	Cabergoline	—	299
14	Ethinyl Estradiol	—	300
15	Ibogaine	—	300
16	streptonigrin	—	299
17	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	—	995
18	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
19	Simvastatin	—	1,000
20	Amoxapine	—	259
21	Antazoline	—	229
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Axitinib	—	298
24	Benzydamine	—	298
25	Calcitriol	—	300
26	Canagliflozin	—	295
27	Carvedilol	—	296
28	Caspofungin	—	299
29	Celecoxib	—	295
30	Cetirizine	—	296
31	Chlorhexidine	—	299
32	Chlorpheniramine	—	298
33	cinacalcet	—	298
34	Cinnarizine	—	299
35	Crizotinib	—	298
36	Cyclizine	—	251
37	Dequalinium	—	136
38	Digitoxin	—	300
39	Domperidone	—	299
40	Estrone	—	300
41	Flunarizine Flunarizine is	—	299
42	Fluspirilene	—	74
43	Fluvoxamine	—	297
44	Hexachlorophene	—	300
45	Indomethacin	—	297
46	Labetalol	—	295
47	Leflunomide	—	297
48	lidoflazine	—	278
49	Loratadine	—	296
50	Maprotiline	—	299

About the Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Pathway

The Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) pathway is catalogued in Reactome (ID: R-HSA-5619081) and involves 1 genes. In the BiohacksAI corpus, 70 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include SLC6A3.