What compounds affect the G1/S Transition pathway?

120 compounds in the BiohacksAI corpus have documented interactions with genes in the G1/S Transition pathway (Reactome ID: R-HSA-69206). These compounds target 54 genes within this pathway.

What genes are in the G1/S Transition pathway?

The G1/S Transition pathway involves 54 genes. Key genes include: ADRM1, AKT3, CCNA1, CCNB1, CCNE2, CDC25A, CDC7, CDK1, CDK2, CDK4.

G1/S Transition

REACTOME PATHWAY

Reactome: R-HSA-6920654 genes120 compounds

The G1/S Transition pathway (Reactome ID: R-HSA-69206) involves 54 genes and is affected by 120 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AKT3 CCNA1 CCNB1 CCNE2 CDC25A CDC7 CDK1 CDK2 CDK4 CDK7 CUL1 DHFR GMNN HDAC1 MYC PCNA PPP2CA PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5+24 more

Compounds Affecting G1/S Transition

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	alsterpaullone	—	12
5	indirubin	—	300
6	sp600125	—	117
7	Sorafenib	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	chrysin	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	Disulfiram	—	297
12	Rotenone	—	300
13	Vorinostat	—	299
14	Dasatinib	—	299
15	Clotrimazole	—	296
16	Vidarabine	—	299
17	fisetin	—	78
18	Quercetin	—	300
19	egcg	—	300
20	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
21	pictilisib	—	25
22	Pemetrexed	—	299
23	Methotrexate	—	289
24	Thymidine Monophosphate 5-Thymidylic acid.	—	202
25	hydroxyfasudil [Supplementary Concept]	—	11
26	Colchicine	—	300
27	2-Methoxyestradiol	—	300
28	Nocodazole Nocodazole is	—	215
29	Astemizole Antihistamine drug now withdrawn from	—	280
30	Metergoline	—	144
31	Podophyllotoxin	—	14
32	triflupromazine hydrochloride	—	12
33	Calcimycin	—	216
34	Digitoxin	—	300
35	Doxazosin	—	24
36	Ethinyl Estradiol	—	300
37	Hexachlorophene	—	300
38	Niclosamide	—	299
39	Duloxetine Hydrochloride	—	993
40	Oleic Acid	—	112
41	ag490	—	14
42	Azacitidine	—	298
43	Azacitidine	—	300
44	Calcifediol	—	300
45	Calcitriol	—	300
46	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
47	cinacalcet	—	298
48	Decitabine	—	298
49	Desogestrel	—	299
50	Dibucaine	—	299

About the G1/S Transition Pathway

The G1/S Transition pathway is catalogued in Reactome (ID: R-HSA-69206) and involves 54 genes. In the BiohacksAI corpus, 120 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AKT3, CCNA1, CCNB1, CCNE2.