What compounds affect the Death Receptor Signaling pathway?

72 compounds in the BiohacksAI corpus have documented interactions with genes in the Death Receptor Signaling pathway (Reactome ID: R-HSA-73887). These compounds target 27 genes within this pathway.

What genes are in the Death Receptor Signaling pathway?

The Death Receptor Signaling pathway involves 27 genes. Key genes include: ADAM17, APH1A, APH1B, BAD, BCL2L11, CASP2, CHUK, HDAC1, HDAC2, HDAC3.

Death Receptor Signaling

REACTOME PATHWAY

Reactome: R-HSA-7388727 genes72 compounds

The Death Receptor Signaling pathway (Reactome ID: R-HSA-73887) involves 27 genes and is affected by 72 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM17 APH1A APH1B BAD BCL2L11 CASP2 CHUK HDAC1 HDAC2 HDAC3 IKBKB IKBKE IRAK1 MAP3K7 MAPK8 MAPKAPK2 NCSTN NFKB1 NFKBIA PSEN1 PSEN2 PSENEN RBCK1 RELA RIPK2 TBK1 ULK1

Compounds Affecting Death Receptor Signaling

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Dihydroergocristine	—	187
3	Bortezomib	—	300
4	Ursolic Acid	—	300
5	chicoric acid	—	117
6	pictilisib	—	25
7	Axitinib	—	298
8	Kaempferols	—	300
9	Vorinostat	—	299
10	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
11	scriptaid	—	53
12	Valproic Acid	—	296
13	Butyric Acid	—	300
14	Celecoxib	—	295
15	Daunorubicin	—	298
16	Camptothecin	—	300
17	Sorafenib	—	300
18	Anisomycin	—	247
19	Afatinib	—	297
20	Quercetin	—	300
21	Resveratrol	—	298
22	Podophyllotoxin	—	14
23	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
24	egcg	—	300
25	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
26	Rutin	—	300
27	Withania	—	500
28	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
29	tamarixetin	—	26
30	Trifluridine	—	295
31	withaferin	—	300
32	sp600125	—	117
33	Adenosine Triphosphate	—	300
34	alsterpaullone	—	12
35	amlexanox	—	96
36	Hydrocortisone	—	299
37	Cerulenin	—	300
38	Chlorpropamide	—	300
39	daph	—	2
40	Disulfiram	—	297
41	Hexachlorophene	—	300
42	Hydrocortisone	—	298
43	Lovastatin	—	300
44	ly294002	—	11
45	Promethazine	—	121
46	protriptyline	—	296
47	streptonigrin	—	299
48	Sulfaphenazole	—	300
49	Triamcinolone	—	300
50	tyrphostin 1	—	1

About the Death Receptor Signaling Pathway

The Death Receptor Signaling pathway is catalogued in Reactome (ID: R-HSA-73887) and involves 27 genes. In the BiohacksAI corpus, 72 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM17, APH1A, APH1B, BAD, BCL2L11.