What compounds affect the Cellular responses to stimuli pathway?

740 compounds in the BiohacksAI corpus have documented interactions with genes in the Cellular responses to stimuli pathway (Reactome ID: R-HSA-8953897). These compounds target 222 genes within this pathway.

What genes are in the Cellular responses to stimuli pathway?

The Cellular responses to stimuli pathway involves 222 genes. Key genes include: ABCC1, ABCC3, ABCG2, ABL1, ADCY9, ADRM1, AKT3, ALB, ANXA2, AR.

Cellular responses to stimuli

REACTOME PATHWAY

Reactome: R-HSA-8953897222 genes740 compounds

The Cellular responses to stimuli pathway (Reactome ID: R-HSA-8953897) involves 222 genes and is affected by 740 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCC3 ABCG2 ABL1 ADCY9 ADRM1 AKT3 ALB ANXA2 AR ARNT ATF6 ATM ATP6V1B2 BCL2L1 BLVRA BLVRB BRCA1 CA9 CACNA1H CACNA2D1 CAMK2B CAMK2D CARM1 CCL2 CCNA1 CCNE2 CDK2 CDK4 CDK6+192 more

Compounds Affecting Cellular responses to stimuli

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	sp600125	—	117
4	Colchicine	—	300
5	vinblastine sulfate	—	81
6	Nocodazole Nocodazole is	—	215
7	Podophyllotoxin	—	14
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Vorinostat	—	299
10	Vincristine	—	299
11	Demecolcine	—	246
12	Hexachlorophene	—	300
13	Kaempferols	—	300
14	chrysin	—	300
15	Sorafenib	—	300
16	Reserpine	—	297
17	egcg	—	300
18	cycloheximide	—	300
19	Disulfiram	—	297
20	Dasatinib	—	299
21	Genistein	—	300
22	Niclosamide	—	299
23	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
24	Noscapine	—	300
25	alsterpaullone	—	12
26	Resveratrol	—	298
27	Methylene Blue	—	200
28	Axitinib	—	298
29	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
30	Azacitidine	—	298
31	Azacitidine	—	300
32	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
33	kenpaullone	—	8
34	fisetin	—	78
35	Maytansine	—	300
36	Daunorubicin	—	298
37	Digoxin	—	299
38	Nisoldipine	—	297
39	Anisomycin	—	247
40	Clotrimazole	—	296
41	Astemizole Antihistamine drug now withdrawn from	—	280
42	Celecoxib	—	295
43	Emetine	—	298
44	Masoprocol	—	300
45	Ciclopirox	—	88
46	triolimus [Supplementary Concept]	—	33
47	celastrol	—	300
48	ly294002	—	11
49	Calcimycin	—	216
50	pictilisib	—	25

About the Cellular responses to stimuli Pathway

The Cellular responses to stimuli pathway is catalogued in Reactome (ID: R-HSA-8953897) and involves 222 genes. In the BiohacksAI corpus, 740 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCC3, ABCG2, ABL1, ADCY9.