What compounds affect the Fatty acid metabolism pathway?

597 compounds in the BiohacksAI corpus have documented interactions with genes in the Fatty acid metabolism pathway (Reactome ID: R-HSA-8978868). These compounds target 38 genes within this pathway.

What genes are in the Fatty acid metabolism pathway?

The Fatty acid metabolism pathway involves 38 genes. Key genes include: ABCC1, ACAD11, AKR1C3, ALOX12, ALOX15, ALOX15B, ALOX5, CBR1, CPT2, CYP1A1.

Fatty acid metabolism

REACTOME PATHWAY

Reactome: R-HSA-897886838 genes597 compounds

The Fatty acid metabolism pathway (Reactome ID: R-HSA-8978868) involves 38 genes and is affected by 597 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ACAD11 AKR1C3 ALOX12 ALOX15 ALOX15B ALOX5 CBR1 CPT2 CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2J2 CYP8B1 EPHX2 FAAH2 FASN GPX1 GPX4 HPGD HSD17B3 LTA4H MAPKAPK2 PECR PON1 PPARD PRKAA2+8 more

Compounds Affecting Fatty acid metabolism

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Kaempferols	—	300
5	Hexachlorophene	—	300
6	Rotenone	—	300
7	Masoprocol	—	300
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	Indomethacin	—	297
10	Ethidium	—	300
11	cbd	—	298
12	cannabidiol	—	296
13	Disulfiram	—	297
14	Clotrimazole	—	296
15	Ethoxyquin Antioxidant; also	—	180
16	Genistein	—	300
17	chrysin	—	300
18	Celecoxib	—	295
19	Hesperidin	—	300
20	Linoleic Acid	—	300
21	Kaempferols	—	300
22	Niclosamide	—	299
23	Berberine	—	300
24	Chlorhexidine	—	299
25	Sulindac	—	297
26	Vitamin	—	295
27	Gemfibrozil	—	297
28	Miconazole	—	298
29	amlexanox	—	96
30	Aurintricarboxylic Acid	—	184
31	ethopropazine hydrochloride	—	2
32	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
33	Pseudoephedrine	—	298
34	Ursolic Acid	—	300
35	Arachidonic Acid	—	245
36	Dipyrone	—	298
37	Ethinyl Estradiol	—	300
38	Flutamide	—	298
39	Loratadine	—	296
40	Vitamin K 3	—	300
41	Piribedil	—	300
42	Progesterone	—	299
43	Fenofibrate	—	297
44	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
45	Danazol	—	298
46	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
47	Phenelzine	—	297
48	Troglitazone	—	299
49	egcg	—	300
50	Mepentol [Supplementary Concept]	—	184

About the Fatty acid metabolism Pathway

The Fatty acid metabolism pathway is catalogued in Reactome (ID: R-HSA-8978868) and involves 38 genes. In the BiohacksAI corpus, 597 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ACAD11, AKR1C3, ALOX12, ALOX15.