What compounds affect the RAC1 GTPase cycle pathway?

48 compounds in the BiohacksAI corpus have documented interactions with genes in the RAC1 GTPase cycle pathway (Reactome ID: R-HSA-9013149). These compounds target 24 genes within this pathway.

What genes are in the RAC1 GTPase cycle pathway?

The RAC1 GTPase cycle pathway involves 24 genes. Key genes include: ABL2, ARHGAP35, BCR, BUB1B-PAK6, CDC42, CDC42BPA, CIT, CYBB, EPHA2, NCF1.

RAC1 GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-901314924 genes48 compounds

The RAC1 GTPase cycle pathway (Reactome ID: R-HSA-9013149) involves 24 genes and is affected by 48 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL2 ARHGAP35 BCR BUB1B-PAK6 CDC42 CDC42BPA CIT CYBB EPHA2 NCF1 NISCH NOX1 PAK4 PAK5 PAK6 PIK3R1 PIK3R2 PIK3R3 PKN1 PKN2 PLD2 RAB7A RACGAP1 TAOK3

Compounds Affecting RAC1 GTPase cycle

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	kenpaullone	—	8
3	Axitinib	—	298
4	Crizotinib	—	298
5	Dasatinib	—	299
6	alsterpaullone	—	12
7	Sirolimus	—	300
8	hydroxyfasudil [Supplementary Concept]	—	11
9	pictilisib	—	25
10	ly294002	—	11
11	torin 1	—	10
12	Quercetin	—	300
13	celastrol	—	300
14	Clonidine	—	299
15	Rilmenidine Oxazole derivative that acts as	—	300
16	Idazoxan	—	300
17	Naphazoline	—	298
18	Guanabenz	—	298
19	Oxymetazoline	—	298
20	Guanfacine	—	294
21	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
22	Mescaline Hallucinogenic alkaloid isolated from	—	300
23	Phentolamine	—	300
24	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
25	triolimus [Supplementary Concept]	—	33
26	pterostilbene	—	299
27	Imatinib Mesylate	—	300
28	Wortmannin	—	300
29	alpelisib	—	227
30	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
31	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
32	chrysin	—	300
33	Naloxone	—	299
34	tyrphostin ag 1478	—	4
35	Pueraria	—	300
36	Kaempferols	—	300
37	Catechin	—	300
38	Equilin	—	216
39	Methylene Blue	—	200
40	indirubin	—	300
41	Loxapine	—	30
42	Afatinib	—	297
43	Hydrocortisone	—	299
44	Hydrocortisone	—	298
45	Guanosine Diphosphate	—	300
46	Guanosine Triphosphate Guanosine 5'-(tetrahydrogen triphosphate).	—	300
47	Oleic Acid	—	112
48	casin	—	10

About the RAC1 GTPase cycle Pathway

The RAC1 GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013149) and involves 24 genes. In the BiohacksAI corpus, 48 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL2, ARHGAP35, BCR, BUB1B-PAK6, CDC42.