What compounds affect the Regulation of IFNA/IFNB signaling pathway?

68 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of IFNA/IFNB signaling pathway (Reactome ID: R-HSA-912694). These compounds target 5 genes within this pathway.

What genes are in the Regulation of IFNA/IFNB signaling pathway?

The Regulation of IFNA/IFNB signaling pathway involves 5 genes. Key genes include: IFNB1, PTPN1, PTPN6, STAT1, TYK2.

Regulation of IFNA/IFNB signaling

REACTOME PATHWAY

Reactome: R-HSA-9126945 genes68 compounds

The Regulation of IFNA/IFNB signaling pathway (Reactome ID: R-HSA-912694) involves 5 genes and is affected by 68 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IFNB1 PTPN1 PTPN6 STAT1 TYK2

Compounds Affecting Regulation of IFNA/IFNB signaling

#	Compound	Targets Hit	Studies
1	celastrol	—	300
2	Methylene Blue	—	200
3	Crizotinib	—	298
4	Sorafenib	—	300
5	sp600125	—	117
6	Camptothecin	—	300
7	Ouabain	—	300
8	withaferin	—	300
9	Disulfiram	—	297
10	Idarubicin	—	299
11	Bortezomib	—	300
12	cycloheximide	—	300
13	Emetine	—	298
14	Proscillaridin	—	219
15	Dactinomycin	—	297
16	Daunorubicin	—	298
17	Epirubicin	—	300
18	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
19	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
20	Tripterygium	—	300
21	Azacitidine	—	298
22	Azacitidine	—	300
23	Calcimycin	—	216
24	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
25	kenpaullone	—	8
26	cbd	—	298
27	cannabidiol	—	296
28	Deslanoside Deacetyllanatoside C.	—	89
29	Digitoxin	—	300
30	Digoxin	—	299
31	Feprazone	—	63
32	Leflunomide	—	297
33	triolimus [Supplementary Concept]	—	33
34	Thapsigargin	—	300
35	Genistein	—	300
36	Sertraline	—	1,000
37	Nitrendipine	—	299
38	Phenylbutazone	—	300
39	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
40	Warfarin	—	1,000
41	Afatinib	—	297
42	C75-coenzyme	—	49
43	casin	—	10
44	Fluspirilene	—	74
45	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
46	Trabectedin	—	297
47	tyrphostin ag 1478	—	4
48	Oleanolic Acid	—	300
49	Ursolic Acid	—	300
50	Okadaic Acid	—	300

About the Regulation of IFNA/IFNB signaling Pathway

The Regulation of IFNA/IFNB signaling pathway is catalogued in Reactome (ID: R-HSA-912694) and involves 5 genes. In the BiohacksAI corpus, 68 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IFNB1, PTPN1, PTPN6, STAT1, TYK2.