What compounds affect the TRAF3-dependent IRF activation pathway pathway?

56 compounds in the BiohacksAI corpus have documented interactions with genes in the TRAF3-dependent IRF activation pathway pathway (Reactome ID: R-HSA-918233). These compounds target 5 genes within this pathway.

What genes are in the TRAF3-dependent IRF activation pathway pathway?

The TRAF3-dependent IRF activation pathway pathway involves 5 genes. Key genes include: CREBBP, EP300, IFNB1, IKBKE, TBK1.

TRAF3-dependent IRF activation pathway

REACTOME PATHWAY

Reactome: R-HSA-9182335 genes56 compounds

The TRAF3-dependent IRF activation pathway pathway (Reactome ID: R-HSA-918233) involves 5 genes and is affected by 56 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 IFNB1 IKBKE TBK1

Compounds Affecting TRAF3-dependent IRF activation pathway

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	amlexanox	—	96
3	Camptothecin	—	300
4	Ouabain	—	300
5	withaferin	—	300
6	celastrol	—	300
7	Disulfiram	—	297
8	Idarubicin	—	299
9	Bortezomib	—	300
10	cycloheximide	—	300
11	Emetine	—	298
12	Proscillaridin	—	219
13	Dactinomycin	—	297
14	Daunorubicin	—	298
15	Epirubicin	—	300
16	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
17	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
18	Tripterygium	—	300
19	Azacitidine	—	298
20	Azacitidine	—	300
21	Calcimycin	—	216
22	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
23	kenpaullone	—	8
24	cbd	—	298
25	cannabidiol	—	296
26	Deslanoside Deacetyllanatoside C.	—	89
27	Digitoxin	—	300
28	Digoxin	—	299
29	Feprazone	—	63
30	Leflunomide	—	297
31	triolimus [Supplementary Concept]	—	33
32	Thapsigargin	—	300
33	Genistein	—	300
34	Sertraline	—	1,000
35	Nitrendipine	—	299
36	Phenylbutazone	—	300
37	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
38	Methylene Blue	—	200
39	Warfarin	—	1,000
40	Afatinib	—	297
41	C75-coenzyme	—	49
42	casin	—	10
43	Fluspirilene	—	74
44	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
45	Sorafenib	—	300
46	sp600125	—	117
47	Trabectedin	—	297
48	tyrphostin ag 1478	—	4
49	Papaverine	—	299
50	Colchicine	—	300

About the TRAF3-dependent IRF activation pathway Pathway

The TRAF3-dependent IRF activation pathway pathway is catalogued in Reactome (ID: R-HSA-918233) and involves 5 genes. In the BiohacksAI corpus, 56 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, IFNB1, IKBKE, TBK1.