Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin

Q: What compounds affect the Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin pathway (Reactome ID: R-HSA-9725554). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-97255546 genes71 compounds

The Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin pathway (Reactome ID: R-HSA-9725554) involves 6 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCG2 FABP5 KLK5 KLK7 PRSS3 YAP1

Compounds Affecting Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
3	Genistein	—	300
4	Colchicine	—	300
5	Resveratrol	—	298
6	Rotenone	—	300
7	Pueraria	—	300
8	Azacitidine	—	298
9	Azacitidine	—	300
10	Camptothecin	—	300
11	cycloheximide	—	300
12	Dactinomycin	—	297
13	deguelin [Supplementary Concept]	—	151
14	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
15	Ouabain	—	300
16	Podophyllotoxin	—	14
17	Thapsigargin	—	300
18	Berberine	—	300
19	2-Methoxyestradiol	—	300
20	Anisomycin	—	247
21	Antimycin	—	300
22	Azauridine	—	300
23	Benzalkonium Compounds	—	299
24	celastrol	—	300
25	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
26	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
27	dihydrorotenone	—	13
28	Emetine	—	298
29	Gliotoxin	—	300
30	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
31	Monensin	—	300
32	Monocrotaline	—	300
33	Nigericin	—	300
34	Nocodazole Nocodazole is	—	215
35	Plicamycin	—	72
36	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
37	Tilorone	—	300
38	Tripterygium	—	300
39	Tubercidin	—	300
40	tyrphostin 9	—	2
41	Valinomycin	—	300
42	licochalcone	—	267
43	Quercetin	—	300
44	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
45	chrysin	—	300
46	Kaempferols	—	300
47	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
48	Atorvastatin	—	1,000
49	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
50	Sirolimus	—	300

About the Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Pathway

The Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin pathway is catalogued in Reactome (ID: R-HSA-9725554) and involves 6 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCG2, FABP5, KLK5, KLK7, PRSS3.