What compounds affect the Developmental Cell Lineages pathway?

450 compounds in the BiohacksAI corpus have documented interactions with genes in the Developmental Cell Lineages pathway (Reactome ID: R-HSA-9734767). These compounds target 22 genes within this pathway.

What genes are in the Developmental Cell Lineages pathway?

The Developmental Cell Lineages pathway involves 22 genes. Key genes include: ABCG2, ALDH1A1, ANXA2, CA2, CD74, CFTR, EGFR, ERBB2, ESR1, FABP5.

Developmental Cell Lineages

REACTOME PATHWAY

Reactome: R-HSA-973476722 genes450 compounds

The Developmental Cell Lineages pathway (Reactome ID: R-HSA-9734767) involves 22 genes and is affected by 450 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCG2 ALDH1A1 ANXA2 CA2 CD74 CFTR EGFR ERBB2 ESR1 FABP5 GNMT KIT KLK5 KLK7 MME MUC1 PGR PLA2G1B PNLIP PRSS1 PRSS3 YAP1

Compounds Affecting Developmental Cell Lineages

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Dasatinib	—	299
4	Genistein	—	300
5	Bortezomib	—	300
6	Disulfiram	—	297
7	Resveratrol	—	298
8	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
9	Kaempferols	—	300
10	Estrone	—	300
11	cycloheximide	—	300
12	Hexachlorophene	—	300
13	Daunorubicin	—	298
14	chrysin	—	300
15	rafoxanide	—	172
16	Thiorphan	—	300
17	Dactinomycin	—	297
18	Rotenone	—	300
19	Ethidium	—	300
20	Mestranol	—	300
21	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
22	Niclosamide	—	299
23	Triiodothyronine	—	300
24	vinblastine sulfate	—	81
25	Celecoxib	—	295
26	Quinestrol	—	194
27	Axitinib	—	298
28	Emetine	—	298
29	Podophyllotoxin	—	14
30	Fenofibrate	—	297
31	Nisoldipine	—	297
32	Triamcinolone Acetonide	—	300
33	Dinitrochlorobenzene	—	300
34	Triamcinolone	—	300
35	Budesonide	—	1,000
36	Hydrocortisone	—	299
37	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
38	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
39	candesartan cilexetil [Supplementary Concept]	—	300
40	Furosemide	—	298
41	Hydrocortisone	—	298
42	Methylprednisolone Acetate Methylprednisolone derivative that is used as	—	300
43	Tilorone	—	300
44	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
45	Crizotinib	—	298
46	tyrphostin ag 1478	—	4
47	Afatinib	—	297
48	Levonorgestrel	—	292
49	Norgestrel	—	300
50	Ethinyl Estradiol	—	300

About the Developmental Cell Lineages Pathway

The Developmental Cell Lineages pathway is catalogued in Reactome (ID: R-HSA-9734767) and involves 22 genes. In the BiohacksAI corpus, 450 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCG2, ALDH1A1, ANXA2, CA2, CD74.