What genes are in the Evasion by RSV of host interferon responses pathway?

The Evasion by RSV of host interferon responses pathway involves 6 genes. Key genes include: CREBBP, EIF2AK2, EP300, IFNB1, RBX1, TYK2.

Evasion by RSV of host interferon responses

Q: What compounds affect the Evasion by RSV of host interferon responses pathway?

58 compounds in the BiohacksAI corpus have documented interactions with genes in the Evasion by RSV of host interferon responses pathway (Reactome ID: R-HSA-9833109). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98331096 genes58 compounds

The Evasion by RSV of host interferon responses pathway (Reactome ID: R-HSA-9833109) involves 6 genes and is affected by 58 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EIF2AK2 EP300 IFNB1 RBX1 TYK2

Compounds Affecting Evasion by RSV of host interferon responses

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	sp600125	—	117
3	Axitinib	—	298
4	Camptothecin	—	300
5	Ouabain	—	300
6	withaferin	—	300
7	celastrol	—	300
8	Disulfiram	—	297
9	Idarubicin	—	299
10	Bortezomib	—	300
11	cycloheximide	—	300
12	Emetine	—	298
13	Proscillaridin	—	219
14	Dactinomycin	—	297
15	Daunorubicin	—	298
16	Epirubicin	—	300
17	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
18	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
19	Tripterygium	—	300
20	Azacitidine	—	298
21	Azacitidine	—	300
22	Calcimycin	—	216
23	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
24	kenpaullone	—	8
25	cbd	—	298
26	cannabidiol	—	296
27	Deslanoside Deacetyllanatoside C.	—	89
28	Digitoxin	—	300
29	Digoxin	—	299
30	Feprazone	—	63
31	Leflunomide	—	297
32	triolimus [Supplementary Concept]	—	33
33	Thapsigargin	—	300
34	Genistein	—	300
35	Sertraline	—	1,000
36	Nitrendipine	—	299
37	Phenylbutazone	—	300
38	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
39	Methylene Blue	—	200
40	Warfarin	—	1,000
41	Afatinib	—	297
42	C75-coenzyme	—	49
43	casin	—	10
44	Fluspirilene	—	74
45	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
46	Sorafenib	—	300
47	Trabectedin	—	297
48	tyrphostin ag 1478	—	4
49	Methotrexate	—	289
50	pictilisib	—	25

About the Evasion by RSV of host interferon responses Pathway

The Evasion by RSV of host interferon responses pathway is catalogued in Reactome (ID: R-HSA-9833109) and involves 6 genes. In the BiohacksAI corpus, 58 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EIF2AK2, EP300, IFNB1, RBX1.