What compounds target ADRA1A?

BiohacksAI has identified 121 compounds that interact with ADRA1A (adrenoceptor alpha 1A). Top compounds include: Phentolamine, Tamsulosin, Norepinephrine Precursor of epinephrine that is secreted by, Yohimbine, Idazoxan. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ADRA1A (adrenoceptor alpha 1A)?

ADRA1A is adrenoceptor alpha 1A. It is a molecular target for 121 compounds documented in PubMed bioassay data. UniProt ID: P35348. NCBI Gene ID: 148.

ADRA1A

MOLECULAR TARGET

adrenoceptor alpha 1A

UniProt: P35348 NCBI Gene: 148121 compounds

ADRA1A (adrenoceptor alpha 1A) is targeted by 121 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ADRA1A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Phentolamine	3.85	46
2	Tamsulosin	3.43	30
3	Norepinephrine Precursor of epinephrine that is secreted by	3.37	28
4	Yohimbine	3.26	25
5	Idazoxan	3.00	19
6	Clonidine	2.89	17
7	Mianserin	2.83	16
8	Oxymetazoline	2.77	15
9	Aripiprazole	2.71	14
10	Epinephrine	2.64	13
11	Phenylephrine	2.56	12
12	Quetiapine Fumarate	2.40	10
13	Buspirone	2.20	8
14	Piperoxan	2.20	8
15	Fluoxetine	1.95	6
16	Indoramin	1.95	6
17	Naphazoline	1.95	6
18	Carvedilol	1.79	5
19	Dihydroergotamine	1.79	5
20	Loxapine	1.79	5
21	Methoxamine	1.79	5
22	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.61	4
23	Astemizole Antihistamine drug now withdrawn from	1.61	4
24	Cabergoline	1.61	4
25	Hydroxyzine	1.61	4
26	Promethazine	1.61	4
27	Rilmenidine Oxazole derivative that acts as	1.61	4
28	Tolazoline	1.61	4
29	Trazodone	1.61	4
30	Amlodipine	1.39	3
31	Venlafaxine Hydrochloride	1.39	3
32	Amoxapine	1.39	3
33	Bromocriptine	1.39	3
34	Guanfacine	1.39	3
35	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	1.39	3
36	Lisuride	1.39	3
37	Nortriptyline	1.39	3
38	Nylidrin	1.39	3
39	Pergolide	1.39	3
40	Sertraline	1.10	2
41	Antazoline	1.10	2
42	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	1.10	2
43	candesartan cilexetil [Supplementary Concept]	1.10	2
44	Chlorhexidine	1.10	2
45	Cinnarizine	1.10	2
46	Crizotinib	1.10	2
47	Cyproheptadine	1.10	2
48	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	1.10	2
49	Dihydroergotamine	1.10	2
50	Domperidone	1.10	2

Showing top 50 of 121 compounds. Use the BiohacksAI search to explore all ADRA1A modulators.

About ADRA1A as a Drug Target

ADRA1A (adrenoceptor alpha 1A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 121 compounds with documented ADRA1A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ADRA1A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.