What compounds affect the Hemostasis pathway?

529 compounds in the BiohacksAI corpus have documented interactions with genes in the Hemostasis pathway (Reactome ID: R-HSA-109582). These compounds target 131 genes within this pathway.

What genes are in the Hemostasis pathway?

The Hemostasis pathway involves 131 genes. Key genes include: ABCC4, ABL1, ADRA2A, ADRA2B, ADRA2C, ALB, ANXA2, APP, ARRB1, ATP1B1.

Hemostasis

REACTOME PATHWAY

Reactome: R-HSA-109582131 genes529 compounds

The Hemostasis pathway (Reactome ID: R-HSA-109582) involves 131 genes and is affected by 529 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC4 ABL1 ADRA2A ADRA2B ADRA2C ALB ANXA2 APP ARRB1 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 CD47 CD74 CDC42 CDK2 CDK5 CFL1 CSK F10 F12 F13A1 F3 F5 FGR FYN GNA15+101 more

Compounds Affecting Hemostasis

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Sorafenib	—	300
4	Podophyllotoxin	—	14
5	Vincristine	—	299
6	Vorinostat	—	299
7	Demecolcine	—	246
8	vinblastine sulfate	—	81
9	Noscapine	—	300
10	Maytansine	—	300
11	Dasatinib	—	299
12	Crizotinib	—	298
13	kenpaullone	—	8
14	tyrphostin ag 1478	—	4
15	Perphenazine	—	297
16	Quercetin	—	300
17	Axitinib	—	298
18	alsterpaullone	—	12
19	Amoxapine	—	259
20	sp600125	—	117
21	Camptothecin	—	300
22	Hexachlorophene	—	300
23	pictilisib	—	25
24	Idarubicin	—	299
25	Adenosine Triphosphate	—	300
26	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
27	Daunorubicin	—	298
28	Resveratrol	—	298
29	Carvedilol	—	296
30	Digoxin	—	299
31	Bortezomib	—	300
32	Methylene Blue	—	200
33	Afatinib	—	297
34	Astemizole Antihistamine drug now withdrawn from	—	280
35	Digitoxin	—	300
36	Papaverine	—	299
37	Ouabain	—	300
38	Disulfiram	—	297
39	Niclosamide	—	299
40	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
41	alpelisib	—	227
42	withaferin	—	300
43	cbd	—	298
44	Sertraline	—	1,000
45	Aripiprazole	—	298
46	cannabidiol	—	296
47	Clotrimazole	—	296
48	ly294002	—	11
49	Nisoldipine	—	297
50	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150

About the Hemostasis Pathway

The Hemostasis pathway is catalogued in Reactome (ID: R-HSA-109582) and involves 131 genes. In the BiohacksAI corpus, 529 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC4, ABL1, ADRA2A, ADRA2B, ADRA2C.