What genes are in the Antimicrobial mechanism of IFN-stimulated genes pathway?

The Antimicrobial mechanism of IFN-stimulated genes pathway involves 49 genes. Key genes include: CASP1, CDK1, CHUK, CHURC1-FNTB, EIF2AK2, EIF4A1, EIF4G1, FNTA, FNTB, FURIN.

Antimicrobial mechanism of IFN-stimulated genes

Q: What compounds affect the Antimicrobial mechanism of IFN-stimulated genes pathway?

216 compounds in the BiohacksAI corpus have documented interactions with genes in the Antimicrobial mechanism of IFN-stimulated genes pathway (Reactome ID: R-HSA-1169410). These compounds target 49 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-116941049 genes216 compounds

The Antimicrobial mechanism of IFN-stimulated genes pathway (Reactome ID: R-HSA-1169410) involves 49 genes and is affected by 216 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CASP1 CDK1 CHUK CHURC1-FNTB EIF2AK2 EIF4A1 EIF4G1 FNTA FNTB FURIN HSPA1A HSPA1B HSPA8 IKBKB KPNB1 MAPK3 NPM1 PGGT1B PIM1 PIN1 PPM1B PPP2CA PPP2R5A PTPN2 SNCA SPHK1 STAT1 STAT3 SUMO1 TARBP2+19 more

Compounds Affecting Antimicrobial mechanism of IFN-stimulated genes

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Noscapine	—	300
4	Vincristine	—	299
5	Vorinostat	—	299
6	vinblastine sulfate	—	81
7	Demecolcine	—	246
8	Podophyllotoxin	—	14
9	Maytansine	—	300
10	Hexachlorophene	—	300
11	sp600125	—	117
12	Quercetin	—	300
13	alsterpaullone	—	12
14	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
15	Lovastatin	—	300
16	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
17	Thioridazine	—	35
18	celastrol	—	300
19	Sertraline	—	1,000
20	Adenosine Triphosphate	—	300
21	Chlorhexidine	—	299
22	kenpaullone	—	8
23	Crizotinib	—	298
24	Ergosterol	—	300
25	Gliotoxin	—	300
26	Okadaic Acid	—	300
27	Ethinyl Estradiol	—	300
28	Methylene Blue	—	200
29	Bortezomib	—	300
30	Rotenone	—	300
31	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
32	Niclosamide	—	299
33	Disulfiram	—	297
34	Axitinib	—	298
35	plumbagin [Supplementary Concept]	—	300
36	Reserpine	—	297
37	Genistein	—	300
38	Resveratrol	—	298
39	cycloheximide	—	300
40	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
41	Clotrimazole	—	296
42	chrysin	—	300
43	Clofibrate	—	299
44	Fenofibrate	—	297
45	pd98059	—	7
46	Perphenazine	—	297
47	Astemizole Antihistamine drug now withdrawn from	—	280
48	Cinnarizine	—	299
49	Hydroxyurea	—	300
50	withaferin	—	300

About the Antimicrobial mechanism of IFN-stimulated genes Pathway

The Antimicrobial mechanism of IFN-stimulated genes pathway is catalogued in Reactome (ID: R-HSA-1169410) and involves 49 genes. In the BiohacksAI corpus, 216 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP1, CDK1, CHUK, CHURC1-FNTB, EIF2AK2.