Regulation of actin dynamics for phagocytic cup formation

Q: What compounds affect the Regulation of actin dynamics for phagocytic cup formation pathway?

234 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of actin dynamics for phagocytic cup formation pathway (Reactome ID: R-HSA-2029482). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-202948211 genes234 compounds

The Regulation of actin dynamics for phagocytic cup formation pathway (Reactome ID: R-HSA-2029482) involves 11 genes and is affected by 234 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 BTK CDC42 CFL1 GRB2 HSP90AA1 HSP90AB1 LIMK1 MAPK1 MAPK3 SYK

Compounds Affecting Regulation of actin dynamics for phagocytic cup formation

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	kenpaullone	—	8
3	Dasatinib	—	299
4	Crizotinib	—	298
5	tyrphostin ag 1478	—	4
6	Clotrimazole	—	296
7	triolimus [Supplementary Concept]	—	33
8	Quercetin	—	300
9	alsterpaullone	—	12
10	piceatannol	—	300
11	ag490	—	14
12	withaferin	—	300
13	celastrol	—	300
14	monorden	—	8
15	Idarubicin	—	299
16	pd98059	—	7
17	Tetracycline	—	300
18	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
19	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
20	sp600125	—	117
21	cycloheximide	—	300
22	deguelin [Supplementary Concept]	—	151
23	Disulfiram	—	297
24	fisetin	—	78
25	alpelisib	—	227
26	Axitinib	—	298
27	Nocodazole Nocodazole is	—	215
28	Sertraline	—	1,000
29	Afatinib	—	297
30	Calcitriol	—	300
31	casin	—	10
32	Hexachlorophene	—	300
33	Rotenone	—	300
34	trequinsin hydrochloride	—	1
35	Ciclopirox	—	88
36	daph	—	2
37	Loratadine	—	296
38	Miconazole	—	298
39	gedunin	—	54
40	Novobiocin	—	300
41	caffeic acid	—	300
42	Masoprocol	—	300
43	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
44	2-Chloroadenosine 2-Chloroadenosine.	—	300
45	Calcimycin	—	216
46	Nitroprusside	—	299
47	plumbagin [Supplementary Concept]	—	300
48	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
49	trametinib	—	296
50	Ouabain	—	300

About the Regulation of actin dynamics for phagocytic cup formation Pathway

The Regulation of actin dynamics for phagocytic cup formation pathway is catalogued in Reactome (ID: R-HSA-2029482) and involves 11 genes. In the BiohacksAI corpus, 234 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, BTK, CDC42, CFL1, GRB2.