What compounds affect the Arachidonate metabolism pathway?

569 compounds in the BiohacksAI corpus have documented interactions with genes in the Arachidonate metabolism pathway (Reactome ID: R-HSA-2142753). These compounds target 27 genes within this pathway.

What genes are in the Arachidonate metabolism pathway?

The Arachidonate metabolism pathway involves 27 genes. Key genes include: ABCC1, AKR1C3, ALOX12, ALOX15, ALOX15B, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1.

Arachidonate metabolism

REACTOME PATHWAY

Reactome: R-HSA-214275327 genes569 compounds

The Arachidonate metabolism pathway (Reactome ID: R-HSA-2142753) involves 27 genes and is affected by 569 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 AKR1C3 ALOX12 ALOX15 ALOX15B ALOX5 CBR1 CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2J2 CYP8B1 EPHX2 FAAH2 GPX1 GPX4 HPGD LTA4H MAPKAPK2 PON1 PTGES PTGES3 PTGS2 TBXAS1

Compounds Affecting Arachidonate metabolism

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Kaempferols	—	300
5	Masoprocol	—	300
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
7	Indomethacin	—	297
8	Hexachlorophene	—	300
9	cbd	—	298
10	cannabidiol	—	296
11	Ethoxyquin Antioxidant; also	—	180
12	chrysin	—	300
13	Celecoxib	—	295
14	Hesperidin	—	300
15	Kaempferols	—	300
16	Disulfiram	—	297
17	Clotrimazole	—	296
18	Ethidium	—	300
19	Miconazole	—	298
20	amlexanox	—	96
21	Aurintricarboxylic Acid	—	184
22	ethopropazine hydrochloride	—	2
23	Linoleic Acid	—	300
24	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
25	Pseudoephedrine	—	298
26	Dipyrone	—	298
27	Chlorhexidine	—	299
28	Piribedil	—	300
29	Genistein	—	300
30	Sulindac	—	297
31	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
32	Vitamin	—	295
33	Danazol	—	298
34	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
35	Gemfibrozil	—	297
36	Phenelzine	—	297
37	Troglitazone	—	299
38	alpha-Linolenic Acid	—	300
39	Cisplatin	—	300
40	Iodoacetamide	—	300
41	ns398	—	116
42	pd98059	—	7
43	sulindac sulfide	—	79
44	Naproxen	—	1,000
45	Methyldopa	—	297
46	Triamcinolone	—	300
47	fisetin	—	78
48	plumbagin [Supplementary Concept]	—	300
49	Procarbazine	—	299
50	pterostilbene	—	299

About the Arachidonate metabolism Pathway

The Arachidonate metabolism pathway is catalogued in Reactome (ID: R-HSA-2142753) and involves 27 genes. In the BiohacksAI corpus, 569 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, AKR1C3, ALOX12, ALOX15, ALOX15B.