What compounds affect the DAP12 interactions pathway?

217 compounds in the BiohacksAI corpus have documented interactions with genes in the DAP12 interactions pathway (Reactome ID: R-HSA-2172127). These compounds target 10 genes within this pathway.

What genes are in the DAP12 interactions pathway?

The DAP12 interactions pathway involves 10 genes. Key genes include: BTK, FYN, GRB2, HLA-B, LAT, LCK, PIK3CB, PIK3R1, PIK3R2, SYK.

DAP12 interactions

REACTOME PATHWAY

Reactome: R-HSA-217212710 genes217 compounds

The DAP12 interactions pathway (Reactome ID: R-HSA-2172127) involves 10 genes and is affected by 217 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BTK FYN GRB2 HLA-B LAT LCK PIK3CB PIK3R1 PIK3R2 SYK

Compounds Affecting DAP12 interactions

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Dasatinib	—	299
3	tyrphostin ag 1478	—	4
4	ly294002	—	11
5	pictilisib	—	25
6	kenpaullone	—	8
7	alpelisib	—	227
8	Sorafenib	—	300
9	Sirolimus	—	300
10	Ouabain	—	300
11	sp600125	—	117
12	cycloheximide	—	300
13	Digoxin	—	299
14	Disulfiram	—	297
15	Emetine	—	298
16	piceatannol	—	300
17	Thapsigargin	—	300
18	torin 1	—	10
19	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
20	Axitinib	—	298
21	Bortezomib	—	300
22	Tripterygium	—	300
23	withaferin	—	300
24	cbd	—	298
25	Sertraline	—	1,000
26	Afatinib	—	297
27	Camptothecin	—	300
28	cannabidiol	—	296
29	celastrol	—	300
30	Daunorubicin	—	298
31	Digitoxin	—	300
32	Epirubicin	—	300
33	Proscillaridin	—	219
34	triolimus [Supplementary Concept]	—	33
35	Quercetin	—	300
36	Azacitidine	—	298
37	Azacitidine	—	300
38	Deslanoside Deacetyllanatoside C.	—	89
39	Idarubicin	—	299
40	Dactinomycin	—	297
41	Genistein	—	300
42	Acetic Acid Product of	—	300
43	Swainsonine	—	300
44	Wortmannin	—	300
45	Atorvastatin	—	1,000
46	Simvastatin	—	1,000
47	Methotrexate	—	289
48	Chlorhexidine	—	299
49	Clofarabine	—	298
50	Colchicine	—	300

About the DAP12 interactions Pathway

The DAP12 interactions pathway is catalogued in Reactome (ID: R-HSA-2172127) and involves 10 genes. In the BiohacksAI corpus, 217 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BTK, FYN, GRB2, HLA-B, LAT.