What compounds affect the PI3K/AKT Signaling in Cancer pathway?

362 compounds in the BiohacksAI corpus have documented interactions with genes in the PI3K/AKT Signaling in Cancer pathway (Reactome ID: R-HSA-2219528). These compounds target 44 genes within this pathway.

What genes are in the PI3K/AKT Signaling in Cancer pathway?

The PI3K/AKT Signaling in Cancer pathway involves 44 genes. Key genes include: AKT3, BAD, CASP9, CHUK, CREB1, EGFR, ERBB2, ERBB3, ERBB4, ESR1.

PI3K/AKT Signaling in Cancer

REACTOME PATHWAY

Reactome: R-HSA-221952844 genes362 compounds

The PI3K/AKT Signaling in Cancer pathway (Reactome ID: R-HSA-2219528) involves 44 genes and is affected by 362 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 BAD CASP9 CHUK CREB1 EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FOXO3 FYN GRB2 GSK3A GSK3B KIT LCK MAPKAP1 MDM2 MET MLST8 MTOR NR4A1+14 more

Compounds Affecting PI3K/AKT Signaling in Cancer

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Sorafenib	—	300
3	sp600125	—	117
4	Quercetin	—	300
5	Axitinib	—	298
6	Sirolimus	—	300
7	ly294002	—	11
8	Crizotinib	—	298
9	pictilisib	—	25
10	Afatinib	—	297
11	torin 1	—	10
12	kenpaullone	—	8
13	tyrphostin ag 1478	—	4
14	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
15	Wortmannin	—	300
16	Resveratrol	—	298
17	Kaempferols	—	300
18	chrysin	—	300
19	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
20	Ku 0063794 [Supplementary Concept]	—	7
21	alpelisib	—	227
22	egcg	—	300
23	alsterpaullone	—	12
24	Genistein	—	300
25	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
26	Dactinomycin	—	297
27	Niclosamide	—	299
28	Chlorhexidine	—	299
29	Ciclopirox	—	88
30	Emetine	—	298
31	Nisoldipine	—	297
32	Ethinyl Estradiol	—	300
33	Danazol	—	298
34	Rotenone	—	300
35	Ethidium	—	300
36	cycloheximide	—	300
37	Hexachlorophene	—	300
38	Bortezomib	—	300
39	vinblastine sulfate	—	81
40	Masoprocol	—	300
41	Daunorubicin	—	298
42	Testosterone	—	299
43	o-Phthalaldehyde	—	300
44	Spironolactone	—	298
45	Methylene Blue	—	200
46	Astemizole Antihistamine drug now withdrawn from	—	280
47	Dinitrochlorobenzene	—	300
48	Disulfiram	—	297
49	Everolimus	—	297
50	Simvastatin	—	1,000

About the PI3K/AKT Signaling in Cancer Pathway

The PI3K/AKT Signaling in Cancer pathway is catalogued in Reactome (ID: R-HSA-2219528) and involves 44 genes. In the BiohacksAI corpus, 362 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, BAD, CASP9, CHUK, CREB1.