What compounds affect the Cellular responses to stress pathway?

704 compounds in the BiohacksAI corpus have documented interactions with genes in the Cellular responses to stress pathway (Reactome ID: R-HSA-2262752). These compounds target 187 genes within this pathway.

What genes are in the Cellular responses to stress pathway?

The Cellular responses to stress pathway involves 187 genes. Key genes include: ABCC1, ABCC3, ABCG2, ADRM1, AKT3, ALB, AR, ARNT, ATF6, ATM.

Cellular responses to stress

REACTOME PATHWAY

Reactome: R-HSA-2262752187 genes704 compounds

The Cellular responses to stress pathway (Reactome ID: R-HSA-2262752) involves 187 genes and is affected by 704 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC1 ABCC3 ABCG2 ADRM1 AKT3 ALB AR ARNT ATF6 ATM ATP6V1B2 BCL2L1 BLVRA BLVRB BRCA1 CA9 CAMK2B CAMK2D CARM1 CCL2 CCNA1 CCNE2 CDK2 CDK4 CDK6 COX1 COX2 CREB1 CREBBP CRYAB+157 more

Compounds Affecting Cellular responses to stress

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Quercetin	—	300
3	vinblastine sulfate	—	81
4	Colchicine	—	300
5	Nocodazole Nocodazole is	—	215
6	sp600125	—	117
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Podophyllotoxin	—	14
9	Vorinostat	—	299
10	Vincristine	—	299
11	Demecolcine	—	246
12	Kaempferols	—	300
13	chrysin	—	300
14	Reserpine	—	297
15	Hexachlorophene	—	300
16	cycloheximide	—	300
17	egcg	—	300
18	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
19	Noscapine	—	300
20	Disulfiram	—	297
21	Niclosamide	—	299
22	Sorafenib	—	300
23	fisetin	—	78
24	Maytansine	—	300
25	Azacitidine	—	298
26	Azacitidine	—	300
27	Methylene Blue	—	200
28	Genistein	—	300
29	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
30	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
31	Digoxin	—	299
32	Nisoldipine	—	297
33	Resveratrol	—	298
34	Daunorubicin	—	298
35	Dasatinib	—	299
36	Clotrimazole	—	296
37	Celecoxib	—	295
38	Masoprocol	—	300
39	Ciclopirox	—	88
40	Axitinib	—	298
41	Anisomycin	—	247
42	alsterpaullone	—	12
43	Progesterone	—	299
44	Chlorhexidine	—	299
45	Emetine	—	298
46	triolimus [Supplementary Concept]	—	33
47	Methotrexate	—	289
48	Calcimycin	—	216
49	Dihydrotestosterone	—	300
50	Spironolactone	—	298

About the Cellular responses to stress Pathway

The Cellular responses to stress pathway is catalogued in Reactome (ID: R-HSA-2262752) and involves 187 genes. In the BiohacksAI corpus, 704 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC1, ABCC3, ABCG2, ADRM1, AKT3.