What compounds affect the Muscle contraction pathway?

248 compounds in the BiohacksAI corpus have documented interactions with genes in the Muscle contraction pathway (Reactome ID: R-HSA-397014). These compounds target 66 genes within this pathway.

What genes are in the Muscle contraction pathway?

The Muscle contraction pathway involves 66 genes. Key genes include: ABCC9, ALDH2, ANXA2, ASPH, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2.

Muscle contraction

REACTOME PATHWAY

Reactome: R-HSA-39701466 genes248 compounds

The Muscle contraction pathway (Reactome ID: R-HSA-397014) involves 66 genes and is affected by 248 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC9 ALDH2 ANXA2 ASPH ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 CACNA1C CACNA1G CACNA1H CACNA1I CACNA2D2 CAMK2B CAMK2D CES1 DMPK FKBP1B FXYD2 GUCY1A1 GUCY1A2 GUCY1B1 HIPK1 HIPK2+36 more

Compounds Affecting Muscle contraction

#	Compound	Targets Hit	Studies
1	Quinidine	—	298
2	Ouabain	—	300
3	Flunarizine Flunarizine is	—	299
4	Saxitoxin	—	300
5	Digoxin	—	299
6	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
7	Digitoxin	—	300
8	Veratridine	—	300
9	Arachidonic Acid	—	245
10	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
11	Reserpine	—	297
12	Duloxetine Hydrochloride	—	993
13	Dibucaine	—	299
14	Cyproheptadine	—	299
15	Bupivacaine	—	300
16	Astemizole Antihistamine drug now withdrawn from	—	280
17	Clotrimazole	—	296
18	lidoflazine	—	278
19	Cinnarizine	—	299
20	dilazep	—	300
21	Hydroxyzine	—	298
22	Phentolamine	—	300
23	Promethazine	—	296
24	Carvedilol	—	296
25	Disulfiram	—	297
26	Nisoldipine	—	297
27	Benzydamine	—	298
28	Chlorpheniramine	—	298
29	Nortriptyline	—	295
30	protriptyline	—	296
31	Lidocaine	—	299
32	Oxytetracycline	—	300
33	sp600125	—	117
34	Fluoxetine	—	1,000
35	Flecainide	—	297
36	Fluspirilene	—	74
37	Nitrendipine	—	299
38	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
39	Miconazole	—	298
40	Sertraline	—	1,000
41	Calcimycin	—	216
42	Crizotinib	—	298
43	Etidocaine	—	300
44	Riluzole	—	298
45	Mianserin	—	299
46	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
47	Lacosamide	—	297
48	Phenobarbital	—	297
49	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
50	Caffeine	—	299

About the Muscle contraction Pathway

The Muscle contraction pathway is catalogued in Reactome (ID: R-HSA-397014) and involves 66 genes. In the BiohacksAI corpus, 248 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC9, ALDH2, ANXA2, ASPH, ATP1A1.