What compounds affect the G alpha (12/13) signalling events pathway?

144 compounds in the BiohacksAI corpus have documented interactions with genes in the G alpha (12/13) signalling events pathway (Reactome ID: R-HSA-416482). These compounds target 7 genes within this pathway.

What genes are in the G alpha (12/13) signalling events pathway?

The G alpha (12/13) signalling events pathway involves 7 genes. Key genes include: ADRA1A, ADRA1B, ADRA1D, BTK, RHOC, ROCK2, TBXA2R.

G alpha (12/13) signalling events

REACTOME PATHWAY

Reactome: R-HSA-4164827 genes144 compounds

The G alpha (12/13) signalling events pathway (Reactome ID: R-HSA-416482) involves 7 genes and is affected by 144 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRA1A ADRA1B ADRA1D BTK RHOC ROCK2 TBXA2R

Compounds Affecting G alpha (12/13) signalling events

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Amlodipine	—	1,000
3	Losartan	—	1,000
4	Phentolamine	—	300
5	Tamsulosin	—	298
6	Norepinephrine Precursor of epinephrine that is secreted by	—	298
7	Yohimbine	—	299
8	Idazoxan	—	300
9	Clonidine	—	299
10	Mianserin	—	299
11	Oxymetazoline	—	298
12	Epinephrine	—	299
13	Phenylephrine	—	299
14	Quetiapine Fumarate	—	994
15	Buspirone	—	299
16	Piperoxan	—	167
17	Fluoxetine	—	1,000
18	Indoramin	—	250
19	Naphazoline	—	298
20	Carvedilol	—	296
21	Dihydroergotamine	—	299
22	Loxapine	—	225
23	Methoxamine	—	300
24	Hydroxyzine	—	298
25	Tolazoline	—	300
26	Trazodone	—	297
27	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
28	Pergolide	—	299
29	Crizotinib	—	298
30	Cyproheptadine	—	299
31	Dihydroergotamine	—	9
32	eliprodil	—	33
33	Guanabenz	—	298
34	Metergoline	—	144
35	Phenoxybenzamine	—	21
36	amn082	—	29
37	Atenolol	—	297
38	Dexmedetomidine	—	299
39	Labetalol	—	295
40	Lisuride	—	299
41	candesartan cilexetil [Supplementary Concept]	—	300
42	Epirubicin	—	300
43	Ezetimibe	—	296
44	Flutamide	—	298
45	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
46	Norethindrone Acetate Acetate ester of norethindrone that is used as	—	300
47	Phenylpropanolamine	—	300
48	Rifamycins	—	300
49	Rifamycins	—	300
50	Ritonavir	—	298

About the G alpha (12/13) signalling events Pathway

The G alpha (12/13) signalling events pathway is catalogued in Reactome (ID: R-HSA-416482) and involves 7 genes. In the BiohacksAI corpus, 144 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRA1A, ADRA1B, ADRA1D, BTK, RHOC.