What compounds affect the G alpha (z) signalling events pathway?

165 compounds in the BiohacksAI corpus have documented interactions with genes in the G alpha (z) signalling events pathway (Reactome ID: R-HSA-418597). These compounds target 8 genes within this pathway.

What genes are in the G alpha (z) signalling events pathway?

The G alpha (z) signalling events pathway involves 8 genes. Key genes include: ADCY9, ADRA2A, ADRA2B, ADRA2C, GNAI1, GNAS, RGS17, RGS4.

G alpha (z) signalling events

REACTOME PATHWAY

Reactome: R-HSA-4185978 genes165 compounds

The G alpha (z) signalling events pathway (Reactome ID: R-HSA-418597) involves 8 genes and is affected by 165 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 ADRA2A ADRA2B ADRA2C GNAI1 GNAS RGS17 RGS4

Compounds Affecting G alpha (z) signalling events

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Methysergide	—	300
3	Yohimbine	—	299
4	Clonidine	—	299
5	Oxymetazoline	—	298
6	Norepinephrine Precursor of epinephrine that is secreted by	—	298
7	Phentolamine	—	300
8	Idazoxan	—	300
9	Epinephrine	—	299
10	Phenylephrine	—	299
11	Mianserin	—	299
12	Dexmedetomidine	—	299
13	Rilmenidine Oxazole derivative that acts as	—	300
14	Naphazoline	—	298
15	Piperoxan	—	167
16	Bromocriptine	—	299
17	Cabergoline	—	299
18	Dihydroergotamine	—	299
19	Guanfacine	—	294
20	Pergolide	—	299
21	Tolazoline	—	300
22	Carvedilol	—	296
23	Tamsulosin	—	298
24	Fluoxetine	—	1,000
25	Quetiapine Fumarate	—	994
26	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
27	Lisuride	—	299
28	Dihydroergotamine	—	9
29	Guanabenz	—	298
30	Loxapine	—	225
31	Metergoline	—	144
32	Metoclopramide	—	297
33	Phenoxybenzamine	—	21
34	Piribedil	—	300
35	Pramipexole	—	297
36	Promethazine	—	296
37	Trazodone	—	297
38	Amisulpride	—	298
39	Amoxapine	—	259
40	Buspirone	—	299
41	Chlorhexidine	—	299
42	Dihydroergocornine	—	65
43	Ergotamine	—	299
44	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
45	Indoramin	—	250
46	lidoflazine	—	278
47	Maprotiline	—	299
48	Methoxamine	—	300
49	Nebivolol	—	297
50	Nortriptyline	—	295

About the G alpha (z) signalling events Pathway

The G alpha (z) signalling events pathway is catalogued in Reactome (ID: R-HSA-418597) and involves 8 genes. In the BiohacksAI corpus, 165 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, ADRA2A, ADRA2B, ADRA2C, GNAI1.