MAPK targets/ Nuclear events mediated by MAP kinases

Q: What compounds affect the MAPK targets/ Nuclear events mediated by MAP kinases pathway?

144 compounds in the BiohacksAI corpus have documented interactions with genes in the MAPK targets/ Nuclear events mediated by MAP kinases pathway (Reactome ID: R-HSA-450282). These compounds target 18 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-45028218 genes144 compounds

The MAPK targets/ Nuclear events mediated by MAP kinases pathway (Reactome ID: R-HSA-450282) involves 18 genes and is affected by 144 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREB1 DUSP3 FOS JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 PPP2CA RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5

Compounds Affecting MAPK targets/ Nuclear events mediated by MAP kinases

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	fisetin	—	78
3	Sorafenib	—	300
4	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
5	Afatinib	—	297
6	Anisomycin	—	247
7	withaferin	—	300
8	pictilisib	—	25
9	Masoprocol	—	300
10	Quercetin	—	300
11	Dasatinib	—	299
12	hydroxyfasudil [Supplementary Concept]	—	11
13	DEAD-box RNA Helicases	—	169
14	Thioctic Acid	—	298
15	Diphenhydramine	—	14
16	Disulfiram	—	297
17	Thioctic Acid	—	300
18	egcg	—	300
19	Lithocholic Acid	—	300
20	Clotrimazole	—	296
21	Nisoldipine	—	297
22	Nocodazole Nocodazole is	—	215
23	Norepinephrine Precursor of epinephrine that is secreted by	—	298
24	Oxyphenbutazone	—	300
25	Salmeterol Xinafoate	—	227
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	trequinsin hydrochloride	—	1
28	plumbagin [Supplementary Concept]	—	300
29	pd98059	—	7
30	tyrphostin ag 1478	—	4
31	alsterpaullone	—	12
32	kenpaullone	—	8
33	trametinib	—	296
34	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
35	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
36	Axitinib	—	298
37	cardamonin	—	180
38	Hesperidin	—	300
39	Colchicine	—	300
40	glaucarubinone	—	10
41	vinblastine sulfate	—	81
42	Methylene Blue	—	200
43	Amoxapine	—	259
44	Cinnarizine	—	299
45	Clofibrate	—	299
46	Ethoxyquin Antioxidant; also	—	180
47	Fenofibrate	—	297
48	Lovastatin	—	300
49	Lynestrenol	—	299
50	Medroxyprogesterone Acetate	—	299

About the MAPK targets/ Nuclear events mediated by MAP kinases Pathway

The MAPK targets/ Nuclear events mediated by MAP kinases pathway is catalogued in Reactome (ID: R-HSA-450282) and involves 18 genes. In the BiohacksAI corpus, 144 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREB1, DUSP3, FOS, JUN, MAPK1.