What compounds affect the Cilium Assembly pathway?

98 compounds in the BiohacksAI corpus have documented interactions with genes in the Cilium Assembly pathway (Reactome ID: R-HSA-5617833). These compounds target 31 genes within this pathway.

What genes are in the Cilium Assembly pathway?

The Cilium Assembly pathway involves 31 genes. Key genes include: CCT2, CDK1, CSNK1D, CSNK1E, HDAC6, HSP90AA1, MCHR1, NEK2, PLK1, PLK4.

Cilium Assembly

REACTOME PATHWAY

Reactome: R-HSA-561783331 genes98 compounds

The Cilium Assembly pathway (Reactome ID: R-HSA-5617833) involves 31 genes and is affected by 98 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCT2 CDK1 CSNK1D CSNK1E HDAC6 HSP90AA1 MCHR1 NEK2 PLK1 PLK4 PRKACA SSTR3 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBB8B+1 more

Compounds Affecting Cilium Assembly

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vorinostat	—	299
4	Vincristine	—	299
5	Noscapine	—	300
6	Podophyllotoxin	—	14
7	Demecolcine	—	246
8	Maytansine	—	300
9	vinblastine sulfate	—	81
10	sp600125	—	117
11	Quercetin	—	300
12	pictilisib	—	25
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	alsterpaullone	—	12
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	chrysin	—	300
17	fisetin	—	78
18	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
19	Axitinib	—	298
20	Camptothecin	—	300
21	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
22	piceatannol	—	300
23	Masoprocol	—	300
24	Clotrimazole	—	296
25	Disulfiram	—	297
26	Hexachlorophene	—	300
27	Idarubicin	—	299
28	Wortmannin	—	300
29	kenpaullone	—	8
30	Sertraline	—	1,000
31	Sorafenib	—	300
32	Dasatinib	—	299
33	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
34	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
35	scriptaid	—	53
36	Valproic Acid	—	296
37	Daunorubicin	—	298
38	Ursolic Acid	—	300
39	Butyric Acid	—	300
40	Celecoxib	—	295
41	Pueraria	—	300
42	Genistein	—	300
43	Kaempferols	—	300
44	pterostilbene	—	299
45	Bufexamac	—	137
46	butein	—	158
47	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
48	Febuxostat	—	297
49	Hesperidin	—	300
50	pd98059	—	7

About the Cilium Assembly Pathway

The Cilium Assembly pathway is catalogued in Reactome (ID: R-HSA-5617833) and involves 31 genes. In the BiohacksAI corpus, 98 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCT2, CDK1, CSNK1D, CSNK1E, HDAC6.