What compounds affect the MAPK6/MAPK4 signaling pathway?

142 compounds in the BiohacksAI corpus have documented interactions with genes in the MAPK6/MAPK4 signaling pathway (Reactome ID: R-HSA-5687128). These compounds target 47 genes within this pathway.

What genes are in the MAPK6/MAPK4 signaling pathway?

The MAPK6/MAPK4 signaling pathway involves 47 genes. Key genes include: ADRM1, AGO2, CDC42, CDK1, FOXO3, HSPB1, IGF2BP1, JUN, MAPK6, MAPKAPK5.

MAPK6/MAPK4 signaling

REACTOME PATHWAY

Reactome: R-HSA-568712847 genes142 compounds

The MAPK6/MAPK4 signaling pathway (Reactome ID: R-HSA-5687128) involves 47 genes and is affected by 142 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 CDC42 CDK1 FOXO3 HSPB1 IGF2BP1 JUN MAPK6 MAPKAPK5 MYC NCOA3 PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1+17 more

Compounds Affecting MAPK6/MAPK4 signaling

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Disulfiram	—	297
4	egcg	—	300
5	Clotrimazole	—	296
6	Quercetin	—	300
7	hydroxyfasudil [Supplementary Concept]	—	11
8	vinblastine sulfate	—	81
9	Methylene Blue	—	200
10	Cinnarizine	—	299
11	Clofibrate	—	299
12	Ethoxyquin Antioxidant; also	—	180
13	Fenofibrate	—	297
14	Lithocholic Acid	—	300
15	Phenoxybenzamine	—	21
16	Sertraline	—	1,000
17	eliprodil	—	33
18	Methimazole	—	295
19	Nisoldipine	—	297
20	Nocodazole Nocodazole is	—	215
21	Masoprocol	—	300
22	Rotenone	—	300
23	Toxaphene	—	299
24	Danazol	—	298
25	alsterpaullone	—	12
26	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
27	chrysin	—	300
28	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
29	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
30	Colchicine	—	300
31	DEAD-box RNA Helicases	—	169
32	Thioctic Acid	—	298
33	Diphenhydramine	—	14
34	glaucarubinone	—	10
35	Thioctic Acid	—	300
36	Amoxapine	—	259
37	Lovastatin	—	300
38	Lynestrenol	—	299
39	Medroxyprogesterone Acetate	—	299
40	Vitamin K 3	—	300
41	Mestranol	—	300
42	Podophyllotoxin	—	14
43	Promethazine	—	121
44	triflupromazine hydrochloride	—	12
45	Vincamine	—	300
46	Azithromycin	—	1,000
47	Budesonide	—	1,000
48	Fluoxetine	—	1,000
49	Iodine	—	300
50	Mianserin	—	299

About the MAPK6/MAPK4 signaling Pathway

The MAPK6/MAPK4 signaling pathway is catalogued in Reactome (ID: R-HSA-5687128) and involves 47 genes. In the BiohacksAI corpus, 142 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, CDC42, CDK1, FOXO3.