What compounds affect the Interferon gamma signaling pathway?

150 compounds in the BiohacksAI corpus have documented interactions with genes in the Interferon gamma signaling pathway (Reactome ID: R-HSA-877300). These compounds target 16 genes within this pathway.

What genes are in the Interferon gamma signaling pathway?

The Interferon gamma signaling pathway involves 16 genes. Key genes include: CAMK2B, CAMK2D, HLA-A, HLA-B, ICAM1, IFNG, JAK2, MAPK1, MAPK3, PTAFR.

Interferon gamma signaling

REACTOME PATHWAY

Reactome: R-HSA-87730016 genes150 compounds

The Interferon gamma signaling pathway (Reactome ID: R-HSA-877300) involves 16 genes and is affected by 150 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMK2D HLA-A HLA-B ICAM1 IFNG JAK2 MAPK1 MAPK3 PTAFR PTPN1 PTPN2 PTPN6 RAF1 STAT1 SUMO1

Compounds Affecting Interferon gamma signaling

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	alsterpaullone	—	12
3	sp600125	—	117
4	celastrol	—	300
5	Hexachlorophene	—	300
6	Camptothecin	—	300
7	Dasatinib	—	299
8	Ursolic Acid	—	300
9	Tripterygium	—	300
10	Astemizole Antihistamine drug now withdrawn from	—	280
11	Oleanolic Acid	—	300
12	withaferin	—	300
13	kenpaullone	—	8
14	Lithocholic Acid	—	300
15	Methylene Blue	—	200
16	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
17	2-Methoxyestradiol	—	300
18	Bortezomib	—	300
19	cycloheximide	—	300
20	Quercetin	—	300
21	Azathioprine	—	300
22	Crizotinib	—	298
23	Clotrimazole	—	296
24	Dactinomycin	—	297
25	Daunorubicin	—	298
26	Epirubicin	—	300
27	Idarubicin	—	299
28	Podophyllotoxin	—	14
29	Vemurafenib	—	298
30	Progesterone	—	299
31	Cladribine	—	297
32	Trifluridine	—	295
33	Calcimycin	—	216
34	plumbagin [Supplementary Concept]	—	300
35	pd98059	—	7
36	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
37	trametinib	—	296
38	streptonigrin	—	299
39	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
40	Dacarbazine	—	299
41	Anisomycin	—	247
42	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
43	Desoxycorticosterone Acetate	—	300
44	tyrphostin 9	—	2
45	Econazole	—	299
46	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
47	Nocodazole Nocodazole is	—	215
48	Afatinib	—	297
49	Chlorhexidine	—	299
50	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299

About the Interferon gamma signaling Pathway

The Interferon gamma signaling pathway is catalogued in Reactome (ID: R-HSA-877300) and involves 16 genes. In the BiohacksAI corpus, 150 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMK2D, HLA-A, HLA-B, ICAM1.