What compounds affect the RUNX2 regulates bone development pathway?

413 compounds in the BiohacksAI corpus have documented interactions with genes in the RUNX2 regulates bone development pathway (Reactome ID: R-HSA-8941326). These compounds target 12 genes within this pathway.

What genes are in the RUNX2 regulates bone development pathway?

The RUNX2 regulates bone development pathway involves 12 genes. Key genes include: ABL1, AR, CBFB, GLI3, HDAC3, HDAC4, HDAC6, MAPK1, MAPK3, SRC.

RUNX2 regulates bone development

REACTOME PATHWAY

Reactome: R-HSA-894132612 genes413 compounds

The RUNX2 regulates bone development pathway (Reactome ID: R-HSA-8941326) involves 12 genes and is affected by 413 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 AR CBFB GLI3 HDAC3 HDAC4 HDAC6 MAPK1 MAPK3 SRC YAP1 YES1

Compounds Affecting RUNX2 regulates bone development

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Quercetin	—	300
3	Celecoxib	—	295
4	Genistein	—	300
5	Sorafenib	—	300
6	Resveratrol	—	298
7	Kaempferols	—	300
8	Dasatinib	—	299
9	Nocodazole Nocodazole is	—	215
10	Camptothecin	—	300
11	pictilisib	—	25
12	tyrphostin ag 1478	—	4
13	alsterpaullone	—	12
14	kenpaullone	—	8
15	Progesterone	—	299
16	cycloheximide	—	300
17	Ethidium	—	300
18	Dactinomycin	—	297
19	Disulfiram	—	297
20	Azacitidine	—	298
21	Azacitidine	—	300
22	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
23	Clotrimazole	—	296
24	Rotenone	—	300
25	Loratadine	—	296
26	Colchicine	—	300
27	Emetine	—	298
28	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
29	Podophyllotoxin	—	14
30	chrysin	—	300
31	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
32	Imatinib Mesylate	—	300
33	Niclosamide	—	299
34	trequinsin hydrochloride	—	1
35	Febuxostat	—	297
36	triflupromazine hydrochloride	—	12
37	Pueraria	—	300
38	Vorinostat	—	299
39	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
40	scriptaid	—	53
41	Valproic Acid	—	296
42	Ursolic Acid	—	300
43	Butyric Acid	—	300
44	Axitinib	—	298
45	pd98059	—	7
46	Crizotinib	—	298
47	Dihydrotestosterone	—	300
48	Testosterone	—	299
49	Medroxyprogesterone Acetate	—	299
50	Spironolactone	—	298

About the RUNX2 regulates bone development Pathway

The RUNX2 regulates bone development pathway is catalogued in Reactome (ID: R-HSA-8941326) and involves 12 genes. In the BiohacksAI corpus, 413 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, AR, CBFB, GLI3, HDAC3.