What compounds affect the RHO GTPase cycle pathway?

164 compounds in the BiohacksAI corpus have documented interactions with genes in the RHO GTPase cycle pathway (Reactome ID: R-HSA-9012999). These compounds target 49 genes within this pathway.

What genes are in the RHO GTPase cycle pathway?

The RHO GTPase cycle pathway involves 49 genes. Key genes include: ABL2, ARHGAP35, BCR, BUB1B-PAK6, CCDC88A, CCT2, CDC37, CDC42, CDC42BPA, CDC42BPB.

RHO GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-901299949 genes164 compounds

The RHO GTPase cycle pathway (Reactome ID: R-HSA-9012999) involves 49 genes and is affected by 164 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL2 ARHGAP35 BCR BUB1B-PAK6 CCDC88A CCT2 CDC37 CDC42 CDC42BPA CDC42BPB CFTR CIT CSK CYBB EPHA2 GRB2 HSP90AA1 HSP90AB1 HSPE1 LCK NCF1 NISCH NOX1 PAK4 PAK5 PAK6 PDE5A PIK3R1 PIK3R2 PIK3R3+19 more

Compounds Affecting RHO GTPase cycle

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Dasatinib	—	299
3	Sorafenib	—	300
4	kenpaullone	—	8
5	Axitinib	—	298
6	alsterpaullone	—	12
7	Quercetin	—	300
8	celastrol	—	300
9	Afatinib	—	297
10	hydroxyfasudil [Supplementary Concept]	—	11
11	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
12	Hexachlorophene	—	300
13	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
14	cycloheximide	—	300
15	Methylene Blue	—	200
16	triolimus [Supplementary Concept]	—	33
17	monorden	—	8
18	Idarubicin	—	299
19	piceatannol	—	300
20	tyrphostin ag 1478	—	4
21	sp600125	—	117
22	Sirolimus	—	300
23	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
24	Vorinostat	—	299
25	Hydrocortisone	—	299
26	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
27	Hydrocortisone	—	298
28	Disulfiram	—	297
29	Niclosamide	—	299
30	Nocodazole Nocodazole is	—	215
31	Podophyllotoxin	—	14
32	rafoxanide	—	172
33	vinblastine sulfate	—	81
34	gedunin	—	54
35	Novobiocin	—	300
36	caffeic acid	—	300
37	Masoprocol	—	300
38	Tetracycline	—	300
39	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
40	ag490	—	14
41	Clotrimazole	—	296
42	Nitroprusside	—	299
43	Wortmannin	—	300
44	Swainsonine	—	300
45	egcg	—	300
46	Aurintricarboxylic Acid	—	184
47	Edaravone	—	298
48	pictilisib	—	25
49	ly294002	—	11
50	torin 1	—	10

About the RHO GTPase cycle Pathway

The RHO GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9012999) and involves 49 genes. In the BiohacksAI corpus, 164 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL2, ARHGAP35, BCR, BUB1B-PAK6, CCDC88A.