What compounds affect the Interferon alpha/beta signaling pathway?

72 compounds in the BiohacksAI corpus have documented interactions with genes in the Interferon alpha/beta signaling pathway (Reactome ID: R-HSA-909733). These compounds target 11 genes within this pathway.

What genes are in the Interferon alpha/beta signaling pathway?

The Interferon alpha/beta signaling pathway involves 11 genes. Key genes include: EIF2AK2, HLA-A, HLA-B, IFNB1, KPNB1, PSMB8, PTPN1, PTPN6, SAMHD1, STAT1.

Interferon alpha/beta signaling

REACTOME PATHWAY

Reactome: R-HSA-90973311 genes72 compounds

The Interferon alpha/beta signaling pathway (Reactome ID: R-HSA-909733) involves 11 genes and is affected by 72 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EIF2AK2 HLA-A HLA-B IFNB1 KPNB1 PSMB8 PTPN1 PTPN6 SAMHD1 STAT1 TYK2

Compounds Affecting Interferon alpha/beta signaling

#	Compound	Targets Hit	Studies
1	celastrol	—	300
2	Crizotinib	—	298
3	Bortezomib	—	300
4	Methylene Blue	—	200
5	sp600125	—	117
6	Camptothecin	—	300
7	Ouabain	—	300
8	withaferin	—	300
9	Disulfiram	—	297
10	Idarubicin	—	299
11	cycloheximide	—	300
12	Emetine	—	298
13	Proscillaridin	—	219
14	Dactinomycin	—	297
15	Daunorubicin	—	298
16	Epirubicin	—	300
17	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
18	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
19	Tripterygium	—	300
20	Azacitidine	—	298
21	Azacitidine	—	300
22	Calcimycin	—	216
23	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
24	kenpaullone	—	8
25	cbd	—	298
26	cannabidiol	—	296
27	Deslanoside Deacetyllanatoside C.	—	89
28	Digitoxin	—	300
29	Digoxin	—	299
30	Feprazone	—	63
31	Leflunomide	—	297
32	triolimus [Supplementary Concept]	—	33
33	Thapsigargin	—	300
34	Genistein	—	300
35	Sertraline	—	1,000
36	Nitrendipine	—	299
37	Phenylbutazone	—	300
38	Sorafenib	—	300
39	Axitinib	—	298
40	Reserpine	—	297
41	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
42	Warfarin	—	1,000
43	Afatinib	—	297
44	C75-coenzyme	—	49
45	casin	—	10
46	Fluspirilene	—	74
47	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
48	Trabectedin	—	297
49	tyrphostin ag 1478	—	4
50	Oleanolic Acid	—	300

About the Interferon alpha/beta signaling Pathway

The Interferon alpha/beta signaling pathway is catalogued in Reactome (ID: R-HSA-909733) and involves 11 genes. In the BiohacksAI corpus, 72 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EIF2AK2, HLA-A, HLA-B, IFNB1, KPNB1.