What compounds affect the Autophagy pathway?

191 compounds in the BiohacksAI corpus have documented interactions with genes in the Autophagy pathway (Reactome ID: R-HSA-9612973). These compounds target 49 genes within this pathway.

What genes are in the Autophagy pathway?

The Autophagy pathway involves 49 genes. Key genes include: ATG4B, ATM, CFTR, CSNK2A1, CSNK2A2, CSNK2B, EPAS1, HBB, HDAC6, HSP90AA1.

Autophagy

REACTOME PATHWAY

Reactome: R-HSA-961297349 genes191 compounds

The Autophagy pathway (Reactome ID: R-HSA-9612973) involves 49 genes and is affected by 191 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATG4B ATM CFTR CSNK2A1 CSNK2A2 CSNK2B EPAS1 HBB HDAC6 HSP90AA1 HSP90AB1 HSPA8 MAP1LC3A MAP1LC3B MLST8 MTOR PIK3C3 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKN RPTOR SRC TBK1 TUBA1A TUBA1B+19 more

Compounds Affecting Autophagy

#	Compound	Targets Hit	Studies
1	Nocodazole Nocodazole is	—	215
2	Colchicine	—	300
3	Vorinostat	—	299
4	Podophyllotoxin	—	14
5	vinblastine sulfate	—	81
6	Vincristine	—	299
7	Noscapine	—	300
8	Demecolcine	—	246
9	Maytansine	—	300
10	Niclosamide	—	299
11	Ursolic Acid	—	300
12	Quercetin	—	300
13	Rotenone	—	300
14	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
15	Adenosine Monophosphate Adenine nucleotide containing	—	300
16	Proguanil	—	299
17	Berberine	—	300
18	Antimycin	—	300
19	Oleanolic Acid	—	300
20	Metformin	—	1,000
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
23	Hexachlorophene	—	300
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	Kaempferols	—	300
26	kenpaullone	—	8
27	pictilisib	—	25
28	chrysin	—	300
29	fisetin	—	78
30	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
31	piceatannol	—	300
32	Novobiocin	—	300
33	Wortmannin	—	300
34	torin 1	—	10
35	ly294002	—	11
36	Crizotinib	—	298
37	Genistein	—	300
38	cycloheximide	—	300
39	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
40	alsterpaullone	—	12
41	Disulfiram	—	297
42	Axitinib	—	298
43	Camptothecin	—	300
44	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
45	triolimus [Supplementary Concept]	—	33
46	monorden	—	8
47	gedunin	—	54
48	Calcimycin	—	216
49	Idarubicin	—	299
50	Sirolimus	—	300

About the Autophagy Pathway

The Autophagy pathway is catalogued in Reactome (ID: R-HSA-9612973) and involves 49 genes. In the BiohacksAI corpus, 191 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATG4B, ATM, CFTR, CSNK2A1, CSNK2A2.